Factors associated with an inconclusive result from commercial homologous recombination deficiency testing in ovarian cancer
Sign Up to like & getrecommendations! Published in 2024 at "Cancer"
DOI: 10.1002/cncr.35523
Abstract: Homologous recombination deficiency (HRD) testing is used to determine the appropriateness of poly ADP‐ribose polymerase inhibitors for patients with epithelial ovarian cancer and no germline/somatic BRCA1/2 alterations. Myriad MyChoice CDx reports a genomic instability score… read more here.
Keywords: cancer; recombination deficiency; factors associated; ovarian cancer ... See more keywords
Association between homologous recombination deficiency and time to treatment failure to platinum-based chemotherapy for pancreatic cancer by using the C-CAT database
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Gastroenterology"
DOI: 10.1007/s00535-024-02173-0
Abstract: Since homologous recombination deficiency (HRD) is relatively uncommon in pancreatic cancer (PC), its impact on time-to-treatment failure (TTF) among patients undergoing systemic chemotherapy for unresectable and recurrent PC remains uncertain. Among patients with unresectable and… read more here.
Keywords: chemotherapy; pancreatic cancer; homologous recombination; recombination deficiency ... See more keywords
Pan-cancer landscape of homologous recombination deficiency
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-19406-4
Abstract: Homologous recombination deficiency (HRD) results in impaired double strand break repair and is a frequent driver of tumorigenesis. Here, we develop a genome-wide mutational scar-based pan-cancer Classifier of HOmologous Recombination Deficiency (CHORD) that can discriminate… read more here.
Keywords: cancer; pan cancer; homologous recombination; recombination deficiency ... See more keywords
Identification of molecular subtypes and prognostic signature for hepatocellular carcinoma based on genes associated with homologous recombination deficiency
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-03432-3
Abstract: Hepatocellular carcinoma (HCC) is a rapidly developing digestive tract carcinoma. The prognosis of patients and side effects caused by clinical treatment should be better improved. Nonnegative matrix factorization (NMF) clustering was performed using 109 homologous… read more here.
Keywords: hepatocellular carcinoma; signature; molecular subtypes; homologous recombination ... See more keywords
ShallowHRD: detection of homologous recombination deficiency from shallow whole genome sequencing
Sign Up to like & getrecommendations! Published in 2020 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btaa261
Abstract: Abstract Summary We introduce shallowHRD, a software tool to evaluate tumor homologous recombination deficiency (HRD) based on whole genome sequencing (WGS) at low coverage (shallow WGS or sWGS; ∼1X coverage). The tool, based on mining… read more here.
Keywords: recombination deficiency; homologous recombination; whole genome; genome sequencing ... See more keywords
Combination of BRCA deep targeted sequencing and shallow whole genome sequencing to detect homologous recombination deficiency in ovarian cancer
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Oncology"
DOI: 10.1101/2024.09.10.24313378
Abstract: Backgrounds: Assessing homologous recombination deficiency (HRD) has been recommended by clinical guidelines for patients with ovarian cancer (OC) as it predicts sensitivity to poly (ADP-ribose) polymerase inhibitors (PARPi). However, HRD testing is complex and either… read more here.
Keywords: oncology; recombination deficiency; sequencing detect; ovarian cancer ... See more keywords
Niraparib maintenance in frontline management of ovarian cancer: a cost effectiveness analysis
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Gynecological Cancer"
DOI: 10.1136/ijgc-2020-001550
Abstract: Objectives Niraparib maintenance after frontline chemotherapy for advanced ovarian cancer extends progression free survival. The objective of this study was to determine the cost effectiveness of niraparib maintenance therapy in patients with newly diagnosed ovarian… read more here.
Keywords: homologous recombination; maintenance; cost; recombination deficiency ... See more keywords
Characterization of TNG348: A Selective, Allosteric USP1 Inhibitor That Synergizes with PARP Inhibitors in Tumors with Homologous Recombination Deficiency
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.mct-24-0515
Abstract: Abstract Inhibition of the deubiquitinating enzyme USP1 can induce synthetic lethality in tumors characterized by homologous recombination deficiency (HRD) and represents a novel therapeutic strategy for the treatment of BRCA1/2-mutant cancers, potentially including patients whose… read more here.
Keywords: tng348 parpi; recombination deficiency; tng348; homologous recombination ... See more keywords
Abstract 2149: A whole genome sequencing classifier of homologous recombination deficiency
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2149
Abstract: Homologous recombination deficiency (HRd) is a DNA repair defect prevalent in but not exclusive to breast and ovarian cancer most commonly associated with BRCA1 or BRCA2 alterations. HRd results in accumulation of small and large… read more here.
Keywords: genome sequencing; hrd; whole genome; recombination deficiency ... See more keywords
Abstract 6610: Detection of homologous recombination deficiency in targeted long read sequenced tumors using mutational signatures
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-6610
Abstract: Homologous recombination deficiency (HRD) affects cancer types including breast, ovarian, pancreas and prostate and patients with HR deficient tumors can respond to poly ADP-ribose polymerase (PARP) inhibitors and platinum-based therapies. HRD is associated to the… read more here.
Keywords: cancer; homologous recombination; mutational signatures; recombination deficiency ... See more keywords
Abstract IA008: Targeting homologous recombination deficiency (HRD) using optimized ionizing radiation and drug combinations
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.dnarepair24-ia008
Abstract: Homologous recombination deficiency (HRD) is found not only in germline mutation carriers of HR genes but is also observed in sporadic cancers when both copies of the HR gene are inactivated. Recognition of HRD is… read more here.
Keywords: deficiency hrd; recombination deficiency; combination; radiation ... See more keywords