Clinical assays for assessment of homologous recombination DNA repair deficiency.
Sign Up to like & getrecommendations! Published in 2020 at "Gynecologic oncology"
DOI: 10.1016/j.ygyno.2020.09.029
Abstract: Homologous recombination DNA repair deficiency (HRD) is a functional defect in homologous recombination DNA repair, arising from germline or somatic mutations in BRCA1/2 or other mechanisms. Cells with HRD are more sensitive to platinum and… read more here.
Keywords: recombination dna; dna repair; dna; hrd ... See more keywords
Krebs Cycle-Deficient Hereditary Cancer Syndromes are Defined by Homologous Recombination DNA Repair Defects
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DOI: 10.1038/s41588-018-0170-4
Abstract: The hereditary cancer syndromes hereditary leiomyomatosis and renal cell cancer (HLRCC) and succinate dehydrogenase–related hereditary paraganglioma and pheochromocytoma (SDH PGL/PCC) are linked to germline loss-of-function mutations in genes encoding the Krebs cycle enzymes fumarate hydratase… read more here.
Keywords: recombination dna; dna repair; dna; homologous recombination ... See more keywords
Editorial: Meiotic Recombination and DNA Repair: New Approaches to Solve Old Questions in Model and Non-model Plant Species
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2022.841402
Abstract: 1 Institut Génétique Reproduction et Développement (iGReD), Université Clermont Auvergne, Centre National de la Recherche Scientifique (CNRS), Institut national de la santé et de la recherche médicale (INSERM), Clermont-Ferrand, France, Department of Life Sciences, Pohang… read more here.
Keywords: dna repair; meiotic recombination; recombination dna; model ... See more keywords
Recombination between T-DNA insertions to cause chromosomal deletions in Arabidopsis is a rare phenomenon
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DOI: 10.7717/peerj.5076
Abstract: We previously described the identification of a chromosomal deletion in Arabidopsis thaliana that resulted in the elimination of genomic DNA between two T-DNA insertions located ca. 25 kilobases apart on chromosome IV. The mechanism responsible… read more here.
Keywords: recombination dna; dna; dna insertions; deletion ... See more keywords