Enhanced prediction of recombination hotspots using input features extracted by class specific autoencoders.
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DOI: 10.1016/j.jtbi.2018.02.016
Abstract: In yeast and in some mammals the frequencies of recombination are high in some genomic locations which are known as recombination hotspots and in the locations where the recombination is below average are consequently known… read more here.
Keywords: specific autoencoders; class specific; features extracted; deep features ... See more keywords
Effects of Demographic History on the Detection of Recombination Hotspots from Linkage Disequilibrium
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DOI: 10.1093/molbev/msx272
Abstract: &NA; In some species, meiotic recombination is concentrated in small genomic regions. These “recombination hotspots” leave signatures in fine‐scale patterns of linkage disequilibrium, raising the prospect that the genomic landscape of hotspots can be characterized… read more here.
Keywords: demographic history; population; recombination; recombination hotspots ... See more keywords
LDSplitDB: a database for studies of meiotic recombination hotspots in MHC using human genomic data
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DOI: 10.1186/s12920-018-0351-0
Abstract: BackgroundMeiotic recombination happens during the process of meiosis when chromosomes inherited from two parents exchange genetic materials to generate chromosomes in the gamete cells. The recombination events tend to occur in narrow genomic regions called… read more here.
Keywords: ldsplitdb database; recombination; recombination hotspots; meiotic recombination ... See more keywords
Identification of recombination hotspots and quantitative trait loci for recombination rate in layer chickens
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DOI: 10.1186/s40104-019-0332-y
Abstract: BackgroundThe frequency of recombination events varies across the genome and between individuals, which may be related to some genomic features. The objective of this study was to assess the frequency of recombination events and to… read more here.
Keywords: trait; recombination events; recombination rate; recombination ... See more keywords
Presence of recombination hotspots throughout SLC6A3
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DOI: 10.1371/journal.pone.0218129
Abstract: The human dopamine transporter gene SLC6A3 is involved in substance use disorders (SUDs) among many other common neuropsychiatric illnesses but allelic association results including those with its classic genetic markers 3’VNTR or Int8VNTR remain mixed… read more here.
Keywords: hotspots throughout; throughout slc6a3; presence recombination; recombination ... See more keywords