Regulation of the MLH1–MLH3 endonuclease in meiosis
Sign Up to like & getrecommendations! Published in 2020 at "Nature"
DOI: 10.1038/s41586-020-2592-2
Abstract: During prophase of the first meiotic division, cells deliberately break their DNA 1 . These DNA breaks are repaired by homologous recombination, which facilitates proper chromosome segregation and enables the reciprocal exchange of DNA segments… read more here.
Keywords: endonuclease; dna; recombination intermediates; mutl ... See more keywords
The topoisomerase 3 zinc finger domain cooperates with the RMI1 scaffold to promote stable association of the BTR complex to recombination intermediates in the Caenorhabditis elegans germline
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac408
Abstract: Abstract Homologous recombination is the predominant DNA repair pathway used in the gonad. Of the excess DNA double-strand breaks formed in meiosis, only a subset matures into crossovers, with the remainder repaired as non-crossovers. The… read more here.
Keywords: recombination; recombination intermediates; rmi1 scaffold; znf ... See more keywords
RMI1 and TOP3α limit meiotic CO formation through their C-terminal domains
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkw1210
Abstract: Abstract At meiosis, hundreds of programmed DNA double-strand breaks (DSBs) form and are repaired by homologous recombination. From this large number of DSBs, only a subset yields crossovers (COs), with a minimum of one CO… read more here.
Keywords: terminal domains; limit; recombination intermediates; recombination ... See more keywords
CDKG1 Is Required for Meiotic and Somatic Recombination Intermediate Processing in Arabidopsis[CC-BY]
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DOI: 10.1105/tpc.19.00942
Abstract: The cyclin-dependent kinase CDKG1 stabilizes recombination intermediates during male meiosis and DNA damage-induced somatic homologous recombination. The Arabidopsis (Arabidopsis thaliana) cyclin-dependent kinase G1 (CDKG1) is necessary for recombination and synapsis during male meiosis at high… read more here.
Keywords: processing; recombination intermediates; cdkg1; recombination ... See more keywords
The conserved LEM-3/Ankle1 nuclease is involved in the combinatorial regulation of meiotic recombination repair and chromosome segregation in Caenorhabditis elegans
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DOI: 10.1371/journal.pgen.1007453
Abstract: Homologous recombination is essential for crossover (CO) formation and accurate chromosome segregation during meiosis. It is of considerable importance to work out how recombination intermediates are processed, leading to CO and non-crossover (NCO) outcome. Genetic… read more here.
Keywords: caenorhabditis elegans; recombination intermediates; chromosome segregation; meiotic recombination ... See more keywords
Unresolved Recombination Intermediates Cause a RAD9-Dependent Cell Cycle Arrest in Saccharomyces cerevisiae
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DOI: 10.1534/genetics.119.302632
Abstract: It has been suggested that the conserved Sgs1-Top3-Rmi1 (STR) helicasedecatenase complex resolves double Holliday junction recombination intermediates (dHJs) as noncrossovers by a process called dissolution. Lichten, Kaur, and GN tested this by accumulating dHJs during… read more here.
Keywords: top3 rmi1; recombination; cell cycle; recombination intermediates ... See more keywords