Homologous recombination repair deficiency (HRD): From biology to clinical exploitation
Sign Up to like & getrecommendations! Published in 2021 at "Genes"
DOI: 10.1002/gcc.22939
Abstract: Significant advances in cancer precision medicine over the last decade have led to a number of treatment options that have significantly improved patient outcomes. The underlying concept integrates detailed insights into disease mechanisms with clinical… read more here.
Keywords: hrd; homologous recombination; biology; recombination repair ... See more keywords
Discovery of Isaindigotone Derivatives as Novel Bloom's Syndrome Protein (BLM) Helicase Inhibitors That Disrupt the BLM/DNA Interactions and Regulate the Homologous Recombination Repair.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.9b00083
Abstract: Homologous recombination repair (HRR), a crucial approach in DNA damage repair, is an attractive target in cancer therapy and drug design. The Bloom syndrome protein (BLM) is a 3'-5' DNA helicase that performs an important… read more here.
Keywords: dna; blm dna; homologous recombination; recombination repair ... See more keywords
Current gene panels account for nearly all homologous recombination repair-associated multiple-case breast cancer families
Sign Up to like & getrecommendations! Published in 2021 at "NPJ Breast Cancer"
DOI: 10.1038/s41523-021-00315-8
Abstract: It was hypothesized that variants in underexplored homologous recombination repair (HR) genes could explain unsolved multiple-case breast cancer (BC) families. We investigated HR deficiency (HRD)-associated mutational signatures and second hits in tumor DNA from familial… read more here.
Keywords: multiple case; breast; homologous recombination; breast cancer ... See more keywords
A plant-specific module for homologous recombination repair
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2202970119
Abstract: Significance DNA damage causes genome instability and numerous diseases including cancers. Homologous recombination repair (HR) is an error-free pathway to repair DNA double-strand breaks, the most serious forms of DNA damage. However, the HR mechanisms… read more here.
Keywords: dna damage; recombination repair; plant; homologous recombination ... See more keywords
Homologous recombination repair deficient prostate cancer represents an immunologically distinct subtype
Sign Up to like & getrecommendations! Published in 2022 at "Oncoimmunology"
DOI: 10.1080/2162402x.2022.2094133
Abstract: ABSTRACT Homologous recombination repair deficiency (HRD) is observed in 10% of patients with castrate-resistant prostate cancer (PCa). Preliminary data suggest that HRD-PCa might be more responsive to immune checkpoint inhibitors (ICIs). In this study, we… read more here.
Keywords: recombination repair; hrd; homologous recombination; hrd pca ... See more keywords
LSD1-LIKE1-Mediated H3K4me2 Demethylation Is Required for Homologous Recombination Repair1
Sign Up to like & getrecommendations! Published in 2019 at "Plant Physiology"
DOI: 10.1104/pp.19.00530
Abstract: LYSINE-SPECIFIC DEMETHYLASE1-LIKE1 promotes homologous recombination repair through demethylation of H3K4me2, maintaining genome stability in Arabidopsis thaliana. Homologous recombination is a key process for maintaining genome integrity and diversity. In eukaryotes, the nucleosome structure of chromatin… read more here.
Keywords: demethylation; homologous recombination; recombination repair; damaged sites ... See more keywords
Chlamydia trachomatis Inhibits Homologous Recombination Repair of DNA Breaks by Interfering with PP2A Signaling
Sign Up to like & getrecommendations! Published in 2018 at "mBio"
DOI: 10.1128/mbio.01465-18
Abstract: Chlamydia trachomatis induces DNA double-strand breaks in host cells but simultaneously inhibits proper DNA damage response and repair mechanisms. This may render host cells prone to loss of genetic integrity and transformation. Here we show… read more here.
Keywords: homologous recombination; pp2a; recombination repair; chlamydia ... See more keywords
ZSTK474 Sensitizes Glioblastoma to Temozolomide by Blocking Homologous Recombination Repair
Sign Up to like & getrecommendations! Published in 2022 at "BioMed Research International"
DOI: 10.1155/2022/8568528
Abstract: Glioblastoma (GBM) is the most common primary malignant brain tumor in adults. Temozolomide (TMZ) is used as the standard chemotherapeutic agent for GBM but with limited success, and treatment failure is mainly due to tumor… read more here.
Keywords: recombination repair; zstk474; gbm; tmz ... See more keywords
Abstract CT269: A phase 2 study of olaparib in combination with pembrolizumab in patients with previously treated advanced solid tumors with homologous recombination repair mutation (HRRm) and/or homologous recombination repair deficiency (HRD): KEYLYNK-007
Sign Up to like & getrecommendations! Published in 2020 at "Tumor Biology"
DOI: 10.1158/1538-7445.am2020-ct269
Abstract: Background: Treatment with the anti-PD-1 antibody pembrolizumab has improved clinical outcomes in multiple previously treated advanced solid tumors. The poly (ADP-ribose) polymerase (PARP) inhibitor olaparib has shown antitumor activity as monotherapy in patients with previously… read more here.
Keywords: solid tumors; advanced solid; treated advanced; homologous recombination ... See more keywords
Abstract 6108: Novel functional dSTRIDE-HR assays to report on the status of homologous recombination repair in cancer cells
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-6108
Abstract: Since the early days of the synthetic lethality concept in DNA Damage Response the status of homologous recombination (HR) repair in cancer cells have been the focus of attention of researchers and clinicians. While different… read more here.
Keywords: dstride assays; recombination repair; status homologous; dstride ... See more keywords
Loss of NFBD1/MDC1 disrupts homologous recombination repair and sensitizes nasopharyngeal carcinoma cells to PARP inhibitors
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biomedical Science"
DOI: 10.1186/s12929-019-0507-z
Abstract: BackgroundNasopharyngeal carcinoma (NPC), a highly invasive tumor, exhibits a distinctive racial and geographic distribution. As options of agents for effective combination chemoradiotherapy for advanced NPC are limited, novel therapeutic approaches are desperately needed. Here the… read more here.
Keywords: combination; carcinoma; homologous recombination; parp inhibition ... See more keywords