In vivo and in vitro reconstitution of unique key steps in cystobactamid antibiotic biosynthesis
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DOI: 10.1038/s41467-021-21848-3
Abstract: Cystobactamids are myxobacteria-derived topoisomerase inhibitors with potent anti-Gram-negative activity. They are formed by a non-ribosomal peptide synthetase (NRPS) and consist of tailored para-aminobenzoic acids, connected by a unique α-methoxy-l-isoasparagine or a β-methoxy-l-asparagine linker moiety. We… read more here.
Keywords: vivo vitro; biosynthesis; vitro reconstitution; reconstitution unique ... See more keywords