A guanine-flipping and sequestration mechanism for G-quadruplex unwinding by RecQ helicases
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-06751-8
Abstract: Homeostatic regulation of G-quadruplexes (G4s), four-stranded structures that can form in guanine-rich nucleic acids, requires G4 unwinding helicases. The mechanisms that mediate G4 unwinding remain unknown. We report the structure of a bacterial RecQ DNA… read more here.
Keywords: flipping sequestration; sequestration mechanism; recq; guanine flipping ... See more keywords
Functional conservation of RecQ helicase BLM between humans and Drosophila melanogaster
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-54101-5
Abstract: RecQ helicases are a family of proteins involved in maintaining genome integrity with functions in DNA repair, recombination, and replication. The human RecQ helicase family consists of five helicases: BLM, WRN, RECQL, RECQL4, and RECQL5.… read more here.
Keywords: functional conservation; recq helicase; drosophila melanogaster; recq ... See more keywords