Magnetic Tweezers-Based Single-Molecule Assays to Study Interaction of E. coli SSB with DNA and RecQ Helicase.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1290-3_6
Abstract: The ability of magnetic tweezers to apply forces and measure molecular displacements has resulted in its extensive use to study the activity of enzymes involved in various aspects of nucleic acid metabolism. These studies have… read more here.
Keywords: single molecule; recq helicase; dna; interaction ... See more keywords
Functional conservation of RecQ helicase BLM between humans and Drosophila melanogaster
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DOI: 10.1038/s41598-019-54101-5
Abstract: RecQ helicases are a family of proteins involved in maintaining genome integrity with functions in DNA repair, recombination, and replication. The human RecQ helicase family consists of five helicases: BLM, WRN, RECQL, RECQL4, and RECQL5.… read more here.
Keywords: functional conservation; recq helicase; drosophila melanogaster; recq ... See more keywords
The RecQ helicase Sgs1 drives ATP-dependent disruption of Rad51 filaments
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkz186
Abstract: Abstract DNA helicases of the RecQ family are conserved among the three domains of life and play essential roles in genome maintenance. Mutations in several human RecQ helicases lead to diseases that are marked by… read more here.
Keywords: recq helicase; sgs1; helicase sgs1; rad51 ... See more keywords
Inhibition of E. coli RecQ Helicase Activity by Structurally Distinct DNA Lesions: Structure—Function Relationships
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DOI: 10.3390/ijms232415654
Abstract: DNA helicase unwinding activity can be inhibited by small molecules and by covalently bound DNA lesions. Little is known about the relationships between the structural features of DNA lesions and their impact on unwinding rates… read more here.
Keywords: coli recq; dna; dna lesions; rate ... See more keywords
RecQ helicase BLM regulates prostate cancer cell proliferation and apoptosis
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DOI: 10.3892/ol.2017.6704
Abstract: Prostate cancer (PCa) is a common malignant tumor and the second leading cause of morbidity and mortality in men worldwide. Considering the prevalence and effects of PCa in males, an understanding of the molecular mechanisms… read more here.
Keywords: recq helicase; prostate cancer; proliferation; pca ... See more keywords