Checkpoint functions of RecQ helicases at perturbed DNA replication fork.
Sign Up to like & getrecommendations! Published in 2021 at "Current genetics"
DOI: 10.1007/s00294-020-01147-y
Abstract: DNA replication checkpoint is a cell signaling pathway that is activated in response to perturbed replication. Although it is crucial for maintaining genomic integrity and cell survival, the exact mechanism of the checkpoint signaling remains… read more here.
Keywords: dna replication; recq helicases; functions recq; replication checkpoint ... See more keywords
RecQ helicases in the malaria parasite Plasmodium falciparum affect genome stability, gene expression patterns and DNA replication dynamics
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DOI: 10.1371/journal.pgen.1007490
Abstract: The malaria parasite Plasmodium falciparum has evolved an unusual genome structure. The majority of the genome is relatively stable, with mutation rates similar to most eukaryotic species. However, some regions are very unstable with high… read more here.
Keywords: malaria parasite; genome stability; dna replication; recq helicases ... See more keywords
Targeting of RecQ Helicases as a Novel Therapeutic Strategy for Ovarian Cancer
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DOI: 10.3390/cancers14051219
Abstract: Simple Summary Ovarian cancer is the most lethal gynecologic malignancy and is characterized by genomic instability and DNA repair defects. PARP inhibitors (PARPi) changed the treatment paradigm of ovarian cancer but the development of resistance… read more here.
Keywords: recq helicases; novel therapeutic; ovarian cancer; resistance ... See more keywords