A phosphatase-recruiting bispecific antibody-aptamer chimera for enhanced suppression of tumor growth.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d3cc01137b
Abstract: The development of agents against abnormal activation of receptor tyrosine kinases (RTKs) for therapeutic interventions is in high demand. Using mesenchymal epithelial transition (Met) protein as a proof-of-concept RTK, here we developed a CD148-recruiting bispecific… read more here.
Keywords: aptamer chimera; recruiting bispecific; antibody aptamer; bispecific antibody ... See more keywords
Platelets subvert antitumor efficacy of T cell-recruiting bispecific antibodies
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-003655
Abstract: T cell-based immunotherapy, for example, with T cell-recruiting bispecific antibody (bsAb), has revolutionized oncological treatment. However, many patients do not respond to treatment, and long-term remissions are still rare. Several tumor immune evasion mechanisms have… read more here.
Keywords: cell; recruiting bispecific; bsab; treatment ... See more keywords