Recruitment of MLL1 complex is essential for SETBP1 to induce myeloid transformation
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DOI: 10.1016/j.isci.2021.103679
Abstract: Summary Abnormal activation of SETBP1 due to overexpression or missense mutations occurs frequently in various myeloid neoplasms and associates with poor prognosis. Direct activation of Hoxa9/Hoxa10/Myb transcription by SETBP1 and its missense mutants is essential… read more here.
Keywords: setbp1; mll1 complex; activation; recruitment mll1 ... See more keywords