Urinary excretion profile of prednisolone and prednisone after rectal administration: Significance in antidoping analysis
Sign Up to like & getrecommendations! Published in 2022 at "Drug Testing and Analysis"
DOI: 10.1002/dta.3352
Abstract: Abstract The rectal administration of glucocorticoids, as well as any injectable, and oral ones, is currently prohibited by the World Anti‐Doping Agency when occurs “in competition.” A reporting level of 100 ng/ml for prednisolone and 300 ng/ml… read more here.
Keywords: prednisolone; administration; prednisone; urinary excretion ... See more keywords
P0080 Thalidomide-Carbomer Gel for Rectal Administration Alleviates DSS-Induced Colitis and fibrosis in Mouse by Targeting S1pr5 and Il1f9 (Il36γ)
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Crohn's and Colitis"
DOI: 10.1093/ecco-jcc/jjae190.0254
Abstract: Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the digestive tract, including ulcerative colitis (UC) and Crohn's disease (CD). Thalidomide, an inhibitor of Tnf-α, is used in IBD treatment but is limited by… read more here.
Keywords: gel; carbomer gel; dss induced; rectal administration ... See more keywords
Rectal administration of metronidazole with and without rectal evacuation prior to use in horses
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Veterinary Pharmacology and Therapeutics"
DOI: 10.1111/jvp.12697
Abstract: In a randomized crossover design study, 10 adult horses were administered crushed metronidazole tablets rectally at 20 mg/kg. Horses' rectums were either evacuated (E) or not evacuated (NE) of manure prior to the administration of the… read more here.
Keywords: administration; without rectal; rectal administration; metronidazole without ... See more keywords
Pharmacokinetics of low-dose and high-dose buprenorphine in cats after rectal administration of different formulations
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Feline Medicine and Surgery"
DOI: 10.1177/1098612x18810933
Abstract: Objectives A prospective experimental study was performed in nine young healthy cats to investigate a pharmacokinetic profile and the clinical relevance of rectally administered buprenorphine. Rectal pH value was measured in all nine cats. Methods… read more here.
Keywords: administration; plasma concentration; rectal administration; high dose ... See more keywords
Penciclovir pharmacokinetics after oral and rectal administration of famciclovir in African elephants (Loxodonta africana) shows that effective concentrations can be achieved from rectal administration, despite lower absorption.
Sign Up to like & getrecommendations! Published in 2024 at "American journal of veterinary research"
DOI: 10.2460/ajvr.24.02.0039
Abstract: OBJECTIVE To evaluate the pharmacokinetics of famciclovir and its metabolite penciclovir following a single dose administered orally and rectally in African elephants (Loxodonta africana). ANIMALS 15 African elephants (6 males and 9 females) of various… read more here.
Keywords: rectal administration; administration; african elephants; absorption ... See more keywords
Pharmacokinetics of Pimobendan and Its Metabolite O-Desmethyl-Pimobendan Following Rectal Administration to Healthy Dogs
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Veterinary Science"
DOI: 10.3389/fvets.2020.00423
Abstract: Objective: This study describes the pharmacokinetics of parent pimobendan (PIM) and its active metabolite, o-desmethyl-pimobendan (ODMP), after oral and rectal administration of pimobendan to healthy dogs. Animals: A total of eight healthy privately owned dogs… read more here.
Keywords: administration; rectal administration; pimobendan; desmethyl pimobendan ... See more keywords