A Dynamic Clinical Calculator for Estimating Conditional Recurrence-Free Survival After Total Neoadjuvant Therapy for Rectal Cancer and Either Surgery or Watch-and-Wait Management
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DOI: 10.1001/jamanetworkopen.2022.33859
Abstract: Key Points Question Can a previously validated clinical calculator be adapted to estimate the risk of rectal cancer recurrence dynamically at different time points for patients who defer surgery after complete response to neoadjuvant therapy?… read more here.
Keywords: free survival; neoadjuvant therapy; recurrence; rectal cancer ... See more keywords
A Clinical Calculator in the Era of Nonoperative Management for Rectal Cancer-How Should We Intensify or Deescalate Surveillance?
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DOI: 10.1001/jamanetworkopen.2022.33868
Abstract: Nonoperative management (watch and wait) is an emerging novel strategy for organ preservation in patients with rectal cancer. Nonoperative management for rectal cancer can be renamed as “surveillance with selective delayed surgery,” in which patients… read more here.
Keywords: surgery; management; management rectal; rectal cancer ... See more keywords
Transcriptomic Analyses of Pretreatment Tumor Biopsy Samples, Response to Neoadjuvant Chemoradiotherapy, and Survival in Patients With Advanced Rectal Cancer
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DOI: 10.1001/jamanetworkopen.2022.52140
Abstract: This case series examines transcriptomic factors associated with outcomes in patients with rectal cancer who received neoadjuvant chemoradiotherapy. read more here.
Keywords: analyses pretreatment; rectal cancer; transcriptomic analyses; neoadjuvant chemoradiotherapy ... See more keywords
Safety and Feasibility of Using Magnetic Resonance Imaging Criteria to Identify Patients With "Good Prognosis" Rectal Cancer Eligible for Primary Surgery: The Phase 2 Nonrandomized QuickSilver Clinical Trial.
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DOI: 10.1001/jamaoncol.2019.0186
Abstract: Importance Chemoradiotherapy (CRT), followed by surgery, is the recommended approach for stage II and III rectal cancer. While CRT decreases the risk of local recurrence, it does not improve survival and leads to poorer functional… read more here.
Keywords: prognosis rectal; surgery; good prognosis; rectal cancer ... See more keywords
Automation of radiation treatment planning for rectal cancer
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DOI: 10.1002/acm2.13712
Abstract: Abstract Purpose To develop an automated workflow for rectal cancer three‐dimensional conformal radiotherapy (3DCRT) treatment planning that combines deep learning (DL) aperture predictions and forward‐planning algorithms. Methods We designed an algorithm to automate the clinical… read more here.
Keywords: rectal cancer; treatment planning; clinically acceptable; cancer ... See more keywords
Oncological outcome after MRI‐based selection for neoadjuvant chemoradiotherapy in the OCUM Rectal Cancer Trial
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DOI: 10.1002/bjs.10879
Abstract: It is not clear whether all patients with rectal cancer need chemoradiotherapy. A restrictive use of neoadjuvant chemoradiotherapy (nCRT) based on MRI findings for rectal cancer was investigated in this study. read more here.
Keywords: rectal cancer; outcome mri; neoadjuvant chemoradiotherapy; oncological outcome ... See more keywords
Postoperative complications in relation to overall treatment time in patients with rectal cancer receiving neoadjuvant radiotherapy
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DOI: 10.1002/bjs.11200
Abstract: The optimal timing of surgery for rectal cancer after radiotherapy (RT) is disputed. The Stockholm III trial concluded that it was oncologically safe to delay surgery for 4–8 weeks after short‐course RT (SRT), with fewer postoperative… read more here.
Keywords: surgery; rectal cancer; radiotherapy; complications relation ... See more keywords
Meta‐analysis of the effect of extending the interval after long‐course chemoradiotherapy before surgery in locally advanced rectal cancer
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DOI: 10.1002/bjs.11220
Abstract: The current standard of care in locally advanced rectal cancer (LARC) is neoadjuvant long‐course chemoradiotherapy (nCRT) followed by total mesorectal excision (TME). Surgery is conventionally performed approximately 6–8 weeks after nCRT. This study aimed to determine… read more here.
Keywords: surgery; rectal cancer; long course; course chemoradiotherapy ... See more keywords
Population‐based study of morbidity risk associated with pathological complete response after chemoradiotherapy for rectal cancer
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DOI: 10.1002/bjs.11324
Abstract: Neoadjuvant chemoradiotherapy (nCRT) for locally advanced rectal cancer may induce a pathological complete response (pCR) but increase surgical morbidity due to radiation‐induced fibrosis. In this study the association between pCR and postoperative surgical morbidity was… read more here.
Keywords: rectal cancer; chemoradiotherapy; pathological complete; morbidity ... See more keywords
Long‐term follow‐up of the randomized trial of mesorectal excision with or without lateral lymph node dissection in rectal cancer (JCOG0212)
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DOI: 10.1002/bjs.11513
Abstract: Japan Clinical Oncology Group (JCOG) 0212 (ClinicalTrials.gov NCT00190541) was a non‐inferiority phase III trial of patients with clinical stage II–III rectal cancer without lateral pelvic lymph node enlargement. The trial compared mesorectal excision (ME) with… read more here.
Keywords: trial; rectal cancer; mesorectal excision; without lateral ... See more keywords
Author response to: Is robotic approach associated with a lower risk of conversion in rectal cancer surgery compared with laparoscopic approach?
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DOI: 10.1002/bjs.11599
Abstract: Editor We would like to thank our colleagues Jia et al. for their thoughtful comments on our study of conversion in robotic versus laparoscopic rectal cancer surgery1. Risk factors for conversion depicted by our multivariate… read more here.
Keywords: risk; surgery; rectal cancer; conversion ... See more keywords