Assessment of Quality of Life Among Patients With Recurrent Clostridioides difficile Infection Treated with Investigational Oral Microbiome Therapeutic SER-109
Sign Up to like & getrecommendations! Published in 2023 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.53570
Abstract: This secondary analysis of a randomized clinical trial examines the association of SER-109 with health-related quality of life in 182 patients with recurrent Clostridioides difficile infection in the US and Canada. read more here.
Keywords: recurrent clostridioides; clostridioides difficile; difficile infection; patients recurrent ... See more keywords
Safety and Tolerability of SER-109 as an Investigational Microbiome Therapeutic in Adults With Recurrent Clostridioides difficile Infection
Sign Up to like & getrecommendations! Published in 2023 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.55758
Abstract: This phase 3, open-label, single-arm trial assesses the safety of SER-109 and the rate of recurrent Clostridioides difficile infection after administration of SER-109 following symptom resolution after antibiotic treatment among adults. read more here.
Keywords: recurrent clostridioides; safety; clostridioides difficile; difficile infection ... See more keywords
Oral Vancomycin for Prevention of Recurrent Clostridioides difficile Infection
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DOI: 10.1001/jamanetworkopen.2025.17834
Abstract: This randomized clinical trial examines whether prophylactic oral vancomycin vs placebo reduces recurrent Clostridioides difficile infection in adults receiving antibiotics for another indication. read more here.
Keywords: clostridioides difficile; recurrent clostridioides; oral vancomycin; difficile infection ... See more keywords
Recurrent Clostridioides (Clostridium) difficile infection in a patient suffering from inflammatory bowel disease and benefits of resistotyping.
Sign Up to like & getrecommendations! Published in 2019 at "Diagnostic microbiology and infectious disease"
DOI: 10.1016/j.diagmicrobio.2019.02.011
Abstract: Two-year Clostridioides (Clostridium) difficile recurrences in a boy with ulcerative colitis are described. Isolates were toxin A/B positive and nonhypervirulent, and resistotypes of 2017 isolates differed from those in 2016, suggesting a reinfection, later confirmed… read more here.
Keywords: clostridium difficile; clostridioides clostridium; difficile infection; recurrent clostridioides ... See more keywords
Fecal microbiota transplantation for recurrent Clostridioides difficile infection associates with functional alterations in circulating microRNAs.
Sign Up to like & getrecommendations! Published in 2021 at "Gastroenterology"
DOI: 10.1053/j.gastro.2021.03.050
Abstract: BACKGROUND AND AIMS The molecular mechanisms underlying successful fecal microbiota transplantation (FMT) for recurrent Clostridioides difficile infection (rCDI) remain poorly understood. The primary objective of this study was to characterize alterations in microRNAs (miRs) following… read more here.
Keywords: fmt; difficile infection; recurrent clostridioides; clostridioides difficile ... See more keywords
Gut microbiota differs between treatment outcomes early after fecal microbiota transplantation against recurrent Clostridioides difficile infection
Sign Up to like & getrecommendations! Published in 2022 at "Gut Microbes"
DOI: 10.1080/19490976.2022.2084306
Abstract: Abstarct In fecal microbiota transplantation (FMT) against recurrent Clostridioides difficile infection (CDI), clinical outcomes are usually determined after 8 weeks. We hypothesized that the intestinal microbiota changes earlier than this timepoint, and analyzed fecal samples… read more here.
Keywords: microbiota transplantation; recurrent clostridioides; microbiota; infection ... See more keywords
P-197. Summary of Recurrent Clostridioides difficile Infections using Whole Genome Sequencing, Minnesota 2019-2021
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DOI: 10.1093/ofid/ofae631.401
Abstract: Abstract Background Recurrent Clostridioides difficile infection (CDI) is typically defined as a positive C. difficile toxin or assay in the 8 weeks following an incident CDI. However, positive detections outside of this timeframe could represent… read more here.
Keywords: incident cdi; recurrent clostridioides; infection; clostridioides difficile ... See more keywords
Efficacy and Safety of Monoclonal Antibodies Against Clostridioides difficile Toxins for Prevention of Recurrent Clostridioides difficile Infection
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Gastroenterology"
DOI: 10.1097/mcg.0000000000001330
Abstract: Supplemental Digital Content is available in the text. Background: Clostridioides difficile infection is one of the most common health care-associated infections. To reduce the recurrent Clostridioides difficile infection (rCDI), monoclonal antibodies against Clostridioides difficile toxin… read more here.
Keywords: difficile infection; clostridioides difficile; recurrent clostridioides; bezlotoxumab ... See more keywords
Novel Biomarkers, Including tcdB PCR Cycle Threshold, for Predicting Recurrent Clostridioides difficile Infection
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DOI: 10.1128/iai.00092-23
Abstract: Traditional clinical models for predicting recurrent Clostridioides difficile infection do not perform well, likely owing to the complex host-pathogen interactions involved. Accurate risk stratification using novel biomarkers could help prevent recurrence by improving underutilization of… read more here.
Keywords: recurrent clostridioides; novel biomarkers; predicting recurrent; clostridioides difficile ... See more keywords
Transmission and clearance of potential procarcinogenic bacteria during fecal microbiota transplantation for recurrent Clostridioides difficile.
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DOI: 10.1172/jci.insight.130848
Abstract: BACKGROUNDFecal microbiota transplantation (FMT) is an effective treatment for recurrent Clostridioides difficile infection (rCDI) in adults and children, but donor stool samples are currently screened for only a limited number of potential pathogens. We sought… read more here.
Keywords: procarcinogenic bacteria; transmission; recurrent clostridioides; clostridioides difficile ... See more keywords
The impact of technical and clinical factors on fecal microbiota transfer outcomes for the treatment of recurrent Clostridioides difficile infections in Germany
Sign Up to like & getrecommendations! Published in 2019 at "United European Gastroenterology Journal"
DOI: 10.1177/2050640619839918
Abstract: Introduction Fecal microbiota transfer (FMT) is highly effective in the treatment and prevention of recurrent Clostridioides difficile infection (rCDI) with cure rates of about 80% after a single treatment. Nevertheless, the reasons for failure in… read more here.
Keywords: microbiota; recurrent clostridioides; treatment; clostridioides difficile ... See more keywords