Dynamic contrast-enhanced MRI may be helpful to predict response and prognosis after bevacizumab treatment in patients with recurrent high-grade glioma: comparison with diffusion tensor and dynamic susceptibility contrast imaging
Sign Up to like & getrecommendations! Published in 2021 at "Neuroradiology"
DOI: 10.1007/s00234-021-02693-z
Abstract: We aimed to evaluate the utility of diffusion tensor imaging (DTI), dynamic contrast-enhanced (DCE), and dynamic susceptibility contrast (DSC) imaging for stratifying bevacizumab treatment outcomes in patients with recurrent high-grade glioma. Fifty-three patients with recurrent… read more here.
Keywords: bevacizumab treatment; contrast; high grade; grade glioma ... See more keywords
A phase 1 trial of intravenous liposomal irinotecan in patients with recurrent high-grade glioma
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-017-3247-3
Abstract: PurposePreclinical activity of irinotecan has been seen in glioma models, but only modest efficacy has been noted in clinical studies, perhaps related to drug distribution and/or pharmacokinetic limitations. In preclinical testing, irinotecan liposome injection (nal-IRI)… read more here.
Keywords: glioma; grade glioma; high grade; patients recurrent ... See more keywords
Salvage re-irradiation for recurrent high-grade glioma and comparison to bevacizumab alone
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DOI: 10.1007/s11060-017-2611-9
Abstract: While salvage re-irradiation is often used for recurrent high-grade glioma (HGG), there have been few comparisons between various re-radiation dose/fractionation schedules or with bevacizumab alone. We analyzed patients with recurrent HGG who received re-irradiation at… read more here.
Keywords: irradiation; high grade; grade glioma; salvage irradiation ... See more keywords
Survival outcomes in pediatric recurrent high-grade glioma: results of a 20-year systematic review and meta-analysis
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DOI: 10.1007/s11060-017-2701-8
Abstract: Recurrent pediatric high-grade glioma is a leading cause of cancer-related death in children. We report results of a systematic review and meta-analysis investigating survival outcome in pediatric patients with recurrent high-grade glioma over the last… read more here.
Keywords: review; recurrent high; grade glioma; high grade ... See more keywords
Retrospective study of nivolumab for patients with recurrent high grade gliomas
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DOI: 10.1007/s11060-018-2907-4
Abstract: IntroductionPatients with recurrent high-grade gliomas (HGG) have limited treatment options. HGG utilize the PD-1 pathway to evade immune responses. Checkpoint inhibitors have demonstrated safety and clinical activity in patients with recurrent glioblastoma. We explored the… read more here.
Keywords: high grade; received nivolumab; grade gliomas; patients recurrent ... See more keywords
Clinical study of apatinib plus temozolomide for the treatment of recurrent high-grade gliomas
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Neuroscience"
DOI: 10.1016/j.jocn.2021.05.032
Abstract: OBJECTIVES Recurrent high-grade glioma, a malignant tumor of the brain or spinal cord associated with poor prognosis with a median survival of 70). Cognition and quality of life improved after treatment and from the safety… read more here.
Keywords: gliomas; treatment; recurrent high; high grade ... See more keywords
Regression of Recurrent High-Grade Glioma with Temozolomide, Dexamethasone, and Levetiracetam: Case Report and Review of the Literature.
Sign Up to like & getrecommendations! Published in 2017 at "World Neurosurgery"
DOI: 10.1016/j.wneu.2017.08.136
Abstract: Background Treatment options for recurrent glioma of the brain include chemotherapy, radiotherapy, surgery, and palliation. Temozolomide appears to be effective in patients with recurrent high-grade gliomas. Case Description A middle-aged woman presented with a high-grade… read more here.
Keywords: grade; grade glioma; high grade; temozolomide dexamethasone ... See more keywords
Locoregional delivery of IL-13Rα2-targeting CAR-T cells in recurrent high-grade glioma: a phase 1 trial
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DOI: 10.1038/s41591-024-02875-1
Abstract: Chimeric antigen receptor T cell (CAR-T) therapy is an emerging strategy to improve treatment outcomes for recurrent high-grade glioma, a cancer that responds poorly to current therapies. Here we report a completed phase I trial… read more here.
Keywords: recurrent high; high grade; trial; grade ... See more keywords
Initial feasibility cohort of temporally modulated pulsed proton re-irradiation (TMPPR) for recurrent high-grade intracranial malignancies
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DOI: 10.1038/s41598-024-78370-x
Abstract: Recurrent high-grade intracranial malignancies have a grim prognosis and uniform management guidelines are lacking. Re-irradiation is underused due to concerns about irreversible side effects. Pulsed-reduced dose rate radiotherapy (PRDR) aims to reduce toxicity while improving… read more here.
Keywords: recurrent high; proton; tmppr; high grade ... See more keywords
Hypofractionated Stereotactic Re-Irradiation with Pembrolizumab and Bevacizumab in Patients with Recurrent High Grade Gliomas: Results from a Phase 1 Study.
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DOI: 10.1093/neuonc/noaa260
Abstract: BACKGROUND Radiotherapy may synergize with programmed death 1 (PD-1)/PD-1 ligand (PD-L1) blockade. The purpose of this study was to determine the recommended Phase II dose, safety/tolerability, and preliminary efficacy of combining pembrolizumab, an anti-PD-1 monoclonal… read more here.
Keywords: bevacizumab; stereotactic irradiation; hypofractionated stereotactic; bevacizumab patients ... See more keywords
SURG-43. PATTERNS OF FAILURE FOLLOWING REIRRADIATION WITH GAMMA KNIFE STEREOTACTIC RADIOSURGERY FOR RECURRENT HIGH-GRADE GLIOMAS
Sign Up to like & getrecommendations! Published in 2024 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noae165.1122
Abstract: Re-irradiation with stereotactic radiosurgery (SRS) is an increasingly used treatment for recurrent high-grade glioma (HGG). We analyzed the patterns of failure and outcomes of salvage Gamma Knife SRS for recurrent HGG to better identify which… read more here.
Keywords: recurrent high; stereotactic radiosurgery; grade; srs ... See more keywords