Dynamic contrast-enhanced MRI may be helpful to predict response and prognosis after bevacizumab treatment in patients with recurrent high-grade glioma: comparison with diffusion tensor and dynamic susceptibility contrast imaging
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DOI: 10.1007/s00234-021-02693-z
Abstract: We aimed to evaluate the utility of diffusion tensor imaging (DTI), dynamic contrast-enhanced (DCE), and dynamic susceptibility contrast (DSC) imaging for stratifying bevacizumab treatment outcomes in patients with recurrent high-grade glioma. Fifty-three patients with recurrent… read more here.
Keywords: bevacizumab treatment; contrast; high grade; grade glioma ... See more keywords
A phase 1 trial of intravenous liposomal irinotecan in patients with recurrent high-grade glioma
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-017-3247-3
Abstract: PurposePreclinical activity of irinotecan has been seen in glioma models, but only modest efficacy has been noted in clinical studies, perhaps related to drug distribution and/or pharmacokinetic limitations. In preclinical testing, irinotecan liposome injection (nal-IRI)… read more here.
Keywords: glioma; grade glioma; high grade; patients recurrent ... See more keywords
Salvage re-irradiation for recurrent high-grade glioma and comparison to bevacizumab alone
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DOI: 10.1007/s11060-017-2611-9
Abstract: While salvage re-irradiation is often used for recurrent high-grade glioma (HGG), there have been few comparisons between various re-radiation dose/fractionation schedules or with bevacizumab alone. We analyzed patients with recurrent HGG who received re-irradiation at… read more here.
Keywords: irradiation; high grade; grade glioma; salvage irradiation ... See more keywords
Survival outcomes in pediatric recurrent high-grade glioma: results of a 20-year systematic review and meta-analysis
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DOI: 10.1007/s11060-017-2701-8
Abstract: Recurrent pediatric high-grade glioma is a leading cause of cancer-related death in children. We report results of a systematic review and meta-analysis investigating survival outcome in pediatric patients with recurrent high-grade glioma over the last… read more here.
Keywords: review; recurrent high; grade glioma; high grade ... See more keywords
Retrospective study of nivolumab for patients with recurrent high grade gliomas
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DOI: 10.1007/s11060-018-2907-4
Abstract: IntroductionPatients with recurrent high-grade gliomas (HGG) have limited treatment options. HGG utilize the PD-1 pathway to evade immune responses. Checkpoint inhibitors have demonstrated safety and clinical activity in patients with recurrent glioblastoma. We explored the… read more here.
Keywords: high grade; received nivolumab; grade gliomas; patients recurrent ... See more keywords
Clinical study of apatinib plus temozolomide for the treatment of recurrent high-grade gliomas
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Neuroscience"
DOI: 10.1016/j.jocn.2021.05.032
Abstract: OBJECTIVES Recurrent high-grade glioma, a malignant tumor of the brain or spinal cord associated with poor prognosis with a median survival of 70). Cognition and quality of life improved after treatment and from the safety… read more here.
Keywords: gliomas; treatment; recurrent high; high grade ... See more keywords
Regression of Recurrent High-Grade Glioma with Temozolomide, Dexamethasone, and Levetiracetam: Case Report and Review of the Literature.
Sign Up to like & getrecommendations! Published in 2017 at "World Neurosurgery"
DOI: 10.1016/j.wneu.2017.08.136
Abstract: Background Treatment options for recurrent glioma of the brain include chemotherapy, radiotherapy, surgery, and palliation. Temozolomide appears to be effective in patients with recurrent high-grade gliomas. Case Description A middle-aged woman presented with a high-grade… read more here.
Keywords: grade; grade glioma; high grade; temozolomide dexamethasone ... See more keywords
Hypofractionated Stereotactic Re-Irradiation with Pembrolizumab and Bevacizumab in Patients with Recurrent High Grade Gliomas: Results from a Phase 1 Study.
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-oncology"
DOI: 10.1093/neuonc/noaa260
Abstract: BACKGROUND Radiotherapy may synergize with programmed death 1 (PD-1)/PD-1 ligand (PD-L1) blockade. The purpose of this study was to determine the recommended Phase II dose, safety/tolerability, and preliminary efficacy of combining pembrolizumab, an anti-PD-1 monoclonal… read more here.
Keywords: bevacizumab; stereotactic irradiation; hypofractionated stereotactic; bevacizumab patients ... See more keywords
ACTR-62. PHASE I TRIAL OF TG02 PLUS DOSE-DENSE OR METRONOMIC TEMOZOLOMIDE FOR RECURRENT HIGH-GRADE ASTROCYTOMA IN ADULTS
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DOI: 10.1093/neuonc/noz175.104
Abstract: Therapies targeting multiple survival pathways are desirable for high-grade gliomas. TG02 (Zotiraciclib), a CDK9 inhibitor, regulates transcription and metabolism of tumor cells and synergizes with temozolomide. A phase I/II trial was launched to test the… read more here.
Keywords: dose level; recurrent high; tg02; high grade ... See more keywords
Patterns of Failure After Stereotactic Radiosurgery for Recurrent High-Grade Glioma: A Single Institution Experience of 10 Years.
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DOI: 10.1093/neuros/nyy520
Abstract: BACKGROUND Stereotactic radiosurgery (SRS) is a treatment modality that is frequently used as salvage therapy for small nodular recurrent high-grade gliomas (HGG). Due to the infiltrative nature of HGG, it is unclear if this highly… read more here.
Keywords: high grade; grade; srs; failure ... See more keywords
18F-Fluciclovine PET/CT in Suspected Residual or Recurrent High-Grade Glioma.
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DOI: 10.1097/rlu.0000000000002641
Abstract: PURPOSE To retrospectively investigate the uptake of F-fluciclovine on PET/CT in patients with suspected recurrent high-grade glioma (HGG). METHODS Twenty-one patients were included. The standard of truth was histopathologic interpretation if available. When histopathology was… read more here.
Keywords: recurrent high; pet; fluciclovine pet; high grade ... See more keywords