The Molecular Landscape of Recurrent and Metastatic Head and Neck Cancers: Insights From a Precision Oncology Sequencing Platform
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DOI: 10.1001/jamaoncol.2016.1790
Abstract: Importance Recurrent and/or metastatic head and neck cancer is usually incurable. Implementation of precision oncology for these patients has been limited by incomplete understanding of the molecular alterations underlying advanced disease. At the same time,… read more here.
Keywords: recurrent metastatic; oncology; head neck;
Cetuximab combined with paclitaxel or paclitaxel alone for patients with recurrent or metastatic head and neck squamous cell carcinoma progressing after EXTREME
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DOI: 10.1002/cam4.3953
Abstract: Prognosis of recurrent or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) remains poor. The addition of cetuximab, to platinum and fluorouracil chemotherapy (EXTREME regimen) has been shown to improve patients’ outcomes in first‐line… read more here.
Keywords: neck squamous; recurrent metastatic; metastatic head; cell carcinoma ... See more keywords
Performance status (PS) as a predictor of poor response to immune checkpoint inhibitors (ICI) in recurrent/metastatic head and neck cancer (RMHNSCC) patients
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DOI: 10.1002/cam4.4722
Abstract: Anti‐PD1 checkpoint inhibitors (ICI) represent an established standard‐of‐care for patients with recurrent/metastatic head and neck squamous cell carcinoma (RMHNSCC). Landmark studies excluded patients with ECOG performance status (PS) ≥2; the benefit of ICI in this… read more here.
Keywords: head neck; metastatic head; checkpoint inhibitors; performance status ... See more keywords
Somatic mutations in tumor and plasma of locoregional recurrent and/or metastatic head and neck cancer using a next‐generation sequencing panel: A preliminary study
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DOI: 10.1002/cam4.5436
Abstract: We explore the utility of TruSight Tumor 170 panel (TST170) for detecting somatic mutations in tumor and cfDNA from locoregional recurrent and/or metastatic head and neck squamous cell carcinoma (HNSCC). read more here.
Keywords: locoregional recurrent; head neck; metastatic head; mutations tumor ... See more keywords
The predictive and prognostic value of weight loss and body composition prior to and during immune checkpoint inhibition in recurrent or metastatic head and neck cancer patients
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DOI: 10.1002/cam4.5522
Abstract: Response rates of immune checkpoint inhibitor (ICI) therapy for recurrent and/or metastatic head and neck squamous cell carcinoma (R/M HNSCC) are low. read more here.
Keywords: metastatic head; recurrent metastatic; head neck; immune checkpoint ... See more keywords
Epstein‐Barr virus‐specific adoptive immunotherapy for recurrent, metastatic nasopharyngeal carcinoma
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DOI: 10.1002/cncr.30541
Abstract: Early‐stage and intermediate‐stage nasopharyngeal cancer (NPC) generally carry a good prognosis, but for patients with recurrent, metastatic disease, options are limited. In the current study, the authors present a phase 1/2 study to evaluate the… read more here.
Keywords: barr virus; recurrent metastatic; epstein barr; immunotherapy ... See more keywords
Identification of preoperative factors associated with outcomes following surgical management of intra‐abdominal recurrent or metastatic GIST following neoadjuvant tyrosine kinase inhibitor therapy
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DOI: 10.1002/jso.24988
Abstract: The role of surgical resection in the treatment of patients with metastatic/recurrent gastrointestinal stromal tumors (GIST) is unclear. The aim of this study was to identify preoperative factors associated with oncologic outcomes for recurrent/metastatic GIST… read more here.
Keywords: recurrent metastatic; preoperative factors; factors associated; kinase inhibitor ... See more keywords
Real-world outcomes of anti-PD1 antibodies in platinum-refractory, PD-L1-positive recurrent and/or metastatic non-small cell lung cancer, and its potential practical predictors: first report from Korean Cancer Study Group LU19-05
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DOI: 10.1007/s00432-021-03527-4
Abstract: Although immune-checkpoint inhibitors have become a new therapeutic option for recurrent/metastatic non-small cell lung cancers (R/M-NSCLC), its clinical benefit in the real-world is still unclear. We investigated 1181 Korean patients with programmed death-1 ligand 1… read more here.
Keywords: recurrent metastatic; real world; metastatic non; group ... See more keywords
Phase II trial of combination treatment with S-1/cetuximab in patients with platinum-ineligible recurrent and/or metastatic squamous cell carcinoma of the head and neck
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DOI: 10.1007/s10147-020-01788-6
Abstract: Background The standard of care for first-line treatment of recurrent and/or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN) in patients who cannot tolerate platinum-based regimens has not been clarified. We aimed… read more here.
Keywords: metastatic squamous; recurrent metastatic; carcinoma head; cell carcinoma ... See more keywords
Treatment of Recurrent or Metastatic Adenoid Cystic Carcinoma
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DOI: 10.1007/s11912-022-01233-z
Abstract: Adenoid cystic carcinoma (ACC) is a rare and heterogeneous malignancy of secretory glands. Recurrence after curative-intent treatment is common, and approximately 40% of patients develop metastatic disease, for which consensus is lacking regarding therapeutic approaches.… read more here.
Keywords: cystic carcinoma; adenoid cystic; treatment; recurrent metastatic ... See more keywords
Established treatment concepts for recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSSC)
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DOI: 10.1007/s12254-020-00645-6
Abstract: Recurrent and metastatic squamous cell carcinomas of the head and neck are still difficult to treat. The EXTREME regimen has been the standard of care for the last decade, but recent studies initiated a change.… read more here.
Keywords: recurrent metastatic; squamous cell; treatment; established treatment ... See more keywords