Re-irradiation for recurrent/progressive pediatric brain tumors: from radiobiology to clinical outcomes.
Sign Up to like & getrecommendations! Published in 2023 at "Expert review of anticancer therapy"
DOI: 10.1080/14737140.2023.2215439
Abstract: INTRODUCTION Brain tumors are the most common solid tumors in children. Neurosurgical excision, radiotherapy, and/or chemotherapy represent the standard of care in most histopathological types of pediatric central nervous system (CNS) tumors. Even though the… read more here.
Keywords: pediatric brain; brain tumors; recurrent progressive; brain ... See more keywords
EPCT-01. PHASE I STUDY OF DAY101 (TAK580) IN CHILDREN AND YOUNG ADULTS WITH RADIOGRAPHICALLY RECURRENT OR PROGRESSIVE LOW-GRADE GLIOMA (LGG)
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaa222.126
Abstract: Abstract BACKGROUND We report a phase I study examining pharmacokinetics, safety and recommended dosage of the type 2 RAF inhibitor DAY101 in children/young adults with radiographically recurrent/progressive LGGs harboring MAPK pathway alterations. METHODS Applying a… read more here.
Keywords: lgg; recurrent progressive; radiographically recurrent; phase study ... See more keywords
The first-in-human phase I study of a brain-penetrant mutant IDH1 inhibitor DS-1001 in patients with recurrent or progressive IDH1-mutant gliomas
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DOI: 10.1093/neuonc/noac155
Abstract: Abstract Background Approximately 70% of lower-grade gliomas harbor isocitrate dehydrogenase 1 (IDH1) mutations, resulting in the accumulation of oncometabolite D-2-hydroxyglutarate (D-2-HG); this leads to epigenetic dysregulation, oncogenesis, and subsequent clonal expansion. DS-1001 is an oral… read more here.
Keywords: idh1 mutant; idh1; recurrent progressive; brain ... See more keywords
Vorasidenib, a Dual Inhibitor of Mutant IDH1/2, in Recurrent or Progressive Glioma; Results of a First-in-Human Phase I Trial
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DOI: 10.1158/1078-0432.ccr-21-0611
Abstract: Purpose: Lower grade gliomas (LGGs) are malignant brain tumors. Current therapy is associated with short- and long-term toxicity. Progression to higher tumor grade is associated with contrast enhancement on MRI. The majority of LGGs harbor… read more here.
Keywords: recurrent progressive; glioma; vorasidenib; mutant idh1 ... See more keywords
Imaging-Based Patterns of Failure following Re-Irradiation for Recurrent/Progressive High-Grade Glioma
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Personalized Medicine"
DOI: 10.3390/jpm13040685
Abstract: Background: Re-irradiation (ReRT) is an effective treatment modality in appropriately selected patients with recurrent/progressive high-grade glioma (HGG). The literature is limited regarding recurrence patterns following ReRT, which was investigated in the current study. Methods: Patients… read more here.
Keywords: progressive high; high grade; recurrent progressive; grade glioma ... See more keywords