GGA1 regulates signal-dependent sorting of BACE1 to recycling endosomes, which moderates Aβ production
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e17-05-0270
Abstract: The diversion of the β-secretase BACE1 from the endo-lysosomal pathway to recycling endosomes is important in the regulation of amyloid beta production. Here we define BACE1 transport from early to recycling endosomes and identify essential… read more here.
Keywords: recycling endosomes; production; signal dependent; gga1 regulates ... See more keywords
WAVE facilitates polarized E-Cadherin transport.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular biology of the cell"
DOI: 10.1091/mbc.e22-08-0322
Abstract: Cadherin dynamics drive morphogenesis, while defects in Cadherin polarity contribute to diseases, including cancers. However, the forces polarizing Cadherin membrane distribution are not well understood. We previously showed that WAVE-dependent branched actin polarizes Cadherin distribution,… read more here.
Keywords: cadherin transport; media see; transport; recycling endosomes ... See more keywords
A Bispecific METxMET Antibody–Drug Conjugate with Cleavable Linker Is Processed in Recycling and Late Endosomes
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.mct-22-0414
Abstract: Abstract Most antibody–drug conjugates (ADC) approved for the treatment of cancer contain protease-cleavable linkers. ADCs that traffic to lysosomes traverse highly acidic late endosomes, while ADCs that recycle to the plasma membrane traffic through mildly… read more here.
Keywords: metxmet antibody; late endosomes; bispecific metxmet; recycling endosomes ... See more keywords
Abstract 124: Recycling endosomes in mature epithelia restrain tumorigenic signaling
Sign Up to like & getrecommendations! Published in 2020 at "Immunology"
DOI: 10.1158/1538-7445.am2020-124
Abstract: The effects of polarized membrane trafficking in mature epithelial tissue on cell growth and cancer progression have not been fully explored in vivo. A majority of colorectal cancers have reduced and mislocalized Rab11, a small… read more here.
Keywords: recycling endosomes; restrain tumorigenic; mature epithelia; epithelia restrain ... See more keywords
Recycling endosomes attach to the trans-side of Golgi stacks in Drosophila and mammalian cells.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of cell science"
DOI: 10.1242/jcs.236935
Abstract: Historically, the trans-Golgi network (TGN) has been recognized as a sorting center of newly synthesized proteins, whereas recycling endosome (RE) is a compartment where endocytosed materials transit before being recycled to the plasma membrane. However,… read more here.
Keywords: recycling endosomes; golgi stacks; drosophila mammalian; mammalian cells ... See more keywords
SNX18 regulates ATG9A trafficking from recycling endosomes by recruiting Dynamin‐2
Sign Up to like & getrecommendations! Published in 2018 at "EMBO Reports"
DOI: 10.15252/embr.201744837
Abstract: Trafficking of mammalian ATG9A between the Golgi apparatus, endosomes and peripheral ATG9A compartments is important for autophagosome biogenesis. Here, we show that the membrane remodelling protein SNX18, previously identified as a positive regulator of autophagy,… read more here.
Keywords: recycling endosomes; snx18; regulates atg9a; atg9a trafficking ... See more keywords
Lipid kinases VPS34 and PIKfyve coordinate a phosphoinositide cascade to regulate retriever-mediated recycling on endosomes
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.69709
Abstract: Cell surface receptors control how cells respond to their environment. Many cell surface receptors recycle from endosomes to the plasma membrane via a recently discovered pathway, which includes sorting-nexin SNX17, Retriever, WASH, and CCC complexes.… read more here.
Keywords: retriever; recycling endosomes; vps34 pikfyve; pikfyve coordinate ... See more keywords