PERK/ATF4-dependent expression of the stress response protein REDD1 promotes proinflammatory cytokine expression in the heart of obese mice
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Physiology - Endocrinology and Metabolism"
DOI: 10.1152/ajpendo.00238.2022
Abstract: Endoplasmic reticulum (ER) stress and inflammation are hallmarks of myocardial impairment. Here we investigated a role for the stress response protein REDD1 as a molecular link between ER stress and inflammation in cardiomyocytes. In mice… read more here.
Keywords: stress; response protein; stress response; perk ... See more keywords
REDD1 deletion attenuates cancer cachexia in mice.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of applied physiology"
DOI: 10.1152/japplphysiol.00536.2021
Abstract: Cancer cachexia is a wasting disorder associated with advanced cancer that contributes to mortality. Cachexia is characterized by involuntary loss of body weight and muscle weakness that affects physical function. Regulated in DNA damage and… read more here.
Keywords: redd1; cancer cachexia; mice; cancer ... See more keywords
Blocking REDD1/TXNIP Complex Ameliorates HG-Induced Renal Tubular Epithelial Cell Apoptosis and EMT through Repressing Oxidative Stress
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Endocrinology"
DOI: 10.1155/2022/6073911
Abstract: Diabetic nephropathy (DN) has become the most common secondary kidney disease causing end-stage renal disease (ESRD). Nevertheless, the underlying mechanisms responsible for DN remain largely unknown. Regulated in development and DNA damage response 1 (REDD1)… read more here.
Keywords: apoptosis; renal tubular; apoptosis emt; redd1 txnip ... See more keywords
Müller Glial Expression of REDD1 is Required for Retinal Neurodegeneration and Visual Dysfunction in Diabetic Mice.
Sign Up to like & getrecommendations! Published in 2022 at "Diabetes"
DOI: 10.2337/db21-0853
Abstract: Clinical studies support a role for the protein regulated in development and DNA damage response 1 (REDD1) in ischemic retinal complications. To better understand how REDD1 contributes to retinal pathology, we examined human single cell… read more here.
Keywords: expression; mice; ller glia; neurodegeneration ... See more keywords
REDD1 Is Involved in Amyloid β-Induced Synaptic Dysfunction and Memory Impairment
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21249482
Abstract: Alzheimer’s disease (AD) is a neurodegenerative disease characterized by neurological dysfunction, including memory impairment, attributed to the accumulation of amyloid β (Aβ) in the brain. Although several studies reported possible mechanisms involved in Aβ pathology,… read more here.
Keywords: induced synaptic; redd1; pathology; synaptic dysfunction ... See more keywords
Nutritional Sensor REDD1 in Cancer and Inflammation: Friend or Foe?
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23179686
Abstract: Regulated in Development and DNA Damage Response 1 (REDD1)/DNA Damage-Induced Transcript 4 (DDIT4) is an immediate early response gene activated by different stress conditions, including growth factor depletion, hypoxia, DNA damage, and stress hormones, i.e.,… read more here.
Keywords: sensor redd1; dna damage; nutritional sensor; redd1 ... See more keywords