Articles with "redesign fluoroquinolones" as a keyword



Toward Catalytic Antibiotics: Redesign of Fluoroquinolones to Catalytically Fragment Chromosomal DNA.

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Published in 2021 at "ACS infectious diseases"

DOI: 10.1021/acsinfecdis.0c00777

Abstract: A library of ciprofloxacin-nuclease conjugates was designed and synthesized to investigate their potential as catalytic antibiotics. The Cu(II) complexes of the new designer compounds (i) showed excellent in vitro hydrolytic and oxidative DNase activity, (ii)… read more here.

Keywords: redesign fluoroquinolones; catalytic antibiotics; dna; fluoroquinolones catalytically ... See more keywords