Flexibility and Design: Conformational Heterogeneity along the Evolutionary Trajectory of a Redesigned Ubiquitin.
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DOI: 10.1016/j.str.2017.03.009
Abstract: Although protein design has been used to introduce new functions, designed variants generally only function as well as natural proteins after rounds of laboratory evolution. One possibility for this pattern is that designed mutants frequently… read more here.
Keywords: protein; flexibility; redesigned ubiquitin; conformational heterogeneity ... See more keywords