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   Articles with "redifferentiation" as a keyword



A novel modified culture medium for enhancing redifferentiation of chondrocytes for cartilage tissue engineering applications

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recommendations! Published in 2022 at "Biotechnology Progress"

DOI: 10.1002/btpr.3240

Abstract: The dedifferentiation of articular chondrocytes during in vitro expansion deteriorates the hyaline cartilage regeneration. Many approaches have been developed to enhance the redifferentiation of chondrocytes. In this study, a new and effective protocol to improve… read more here.

Keywords: culture; redifferentiation chondrocytes; redifferentiation; modified culture ... See more keywords

S100B + A1 CELISA: A Novel Potency Assay and Screening Tool for Redifferentiation Stimuli of Human Articular Chondrocytes

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recommendations! Published in 2017 at "Journal of Cellular Physiology"

DOI: 10.1002/jcp.25682

Abstract: During monolayer expansion, a necessary step in autologous chondrocyte implantation, human articular chondrocytes (HAC) dedifferentiate and lose their capacity to produce stable hyaline cartilage. Determining HAC potency and learning how to trigger their redifferentiation would… read more here.

Keywords: potency; monolayer; redifferentiation; s100b ... See more keywords

Collagen and Alginate Hydrogels Support Chondrocytes Redifferentiation In Vitro without Supplementation of Exogenous Growth Factors

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recommendations! Published in 2024 at "ACS Omega"

DOI: 10.1021/acsomega.4c01675

Abstract: Focal cartilage defects are a prevalent knee problem affecting people of all ages. Articular cartilage (AC) possesses limited healing potential, and osteochondral defects can lead to pain and long-term complications such as osteoarthritis. Autologous chondrocyte… read more here.

Keywords: growth factors; cartilage; redifferentiation; collagen alginate ... See more keywords

Transfection of Peripheral Blood Monocytes with SOX2 Enhances Multipotency, Proliferation, and Redifferentiation into Neohepatocytes and Insulin-Producing Cells

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recommendations! Published in 2018 at "Stem Cells International"

DOI: 10.1155/2018/4271875

Abstract: Following a several-day incubation in medium containing IL-3 and M-CSF to generate a more plastic intermediate “reprogrammed multipotent cells of monocytic origin (RMCMO),” peripheral blood mononuclear cells (PBMCs) can be efficiently converted to hepatocyte-like cells… read more here.

Keywords: producing cells; redifferentiation; proliferation; neohepatocytes insulin ... See more keywords

Enhancing Radioiodine Incorporation into Radioiodine-Refractory Thyroid Cancer with MAPK Inhibition (ERRITI): A Single-Center Prospective Two-Arm Study

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recommendations! Published in 2022 at "Clinical Cancer Research"

DOI: 10.1158/1078-0432.ccr-22-0437

Abstract: Abstract Purpose: Restoration of iodine incorporation (redifferentiation) by MAPK inhibition was achieved in previously radioiodine-refractory, unresectable thyroid carcinoma (RR-TC). However, results were unsatisfactory in BRAFV600E-mutant (BRAF-MUT) RR-TC. Here we assess safety and efficacy of redifferentiation… read more here.

Keywords: arm; redifferentiation; braf; radioiodine refractory ... See more keywords

Dedifferentiation and Redifferentiation of Follicular-Cell-Derived Thyroid Carcinoma: Mechanisms and Therapeutic Implications

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recommendations! Published in 2025 at "Biomedicines"

DOI: 10.3390/biomedicines13122982

Abstract: Follicular-cell-derived thyroid carcinoma, while typically associated with a favorable prognosis, can undergo dedifferentiation into poorly differentiated (PDTC) or anaplastic thyroid carcinoma (ATC), leading to enhanced aggressiveness and radioiodine resistance. This review systematically examines the genetic… read more here.

Keywords: carcinoma; follicular cell; thyroid carcinoma; derived thyroid ... See more keywords

Sinomenine Hydrochloride Promotes TSHR-Dependent Redifferentiation in Papillary Thyroid Cancer

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recommendations! Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms231810709

Abstract: Radioactive iodine (RAI) plays an important role in the diagnosis and treatment of papillary thyroid cancer (PTC). The curative effects of RAI therapy are not only related to radiosensitivity but also closely related to the… read more here.

Keywords: redifferentiation; thyroid; sinomenine hydrochloride; thyroid cancer ... See more keywords