Redox Dependent Activation of NF-kB Signaling in Cancer via Superoxide-Induced Phosphorylation of IKK
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.10.161
Abstract: Evidence over the years has highlighted the importance of intracellular redox status in determining cell fate. To date, our work has shown that a pro-oxidant intracellular milieu, particularly a mild increase in superoxide (O2•‒) promotes… read more here.
Keywords: superoxide; activation; cancer; redox dependent ... See more keywords
Redox-dependent and redox-independent functions of Caenorhabditis elegans thioredoxin 1
Sign Up to like & getrecommendations! Published in 2019 at "Redox Biology"
DOI: 10.1016/j.redox.2019.101178
Abstract: Thioredoxins (TRX) are traditionally considered as enzymes catalyzing redox reactions. However, redox-independent functions of thioredoxins have been described in different organisms, although the underlying molecular mechanisms are yet unknown. We report here the characterization of… read more here.
Keywords: redox independent; redox; independent functions; caenorhabditis elegans ... See more keywords
Redox-dependent structure and dynamics of macrophage migration inhibitory factor reveal sites of latent allostery.
Sign Up to like & getrecommendations! Published in 2022 at "Structure"
DOI: 10.1016/j.str.2022.03.007
Abstract: Macrophage migration inhibitory factor (MIF) is a multifunctional immunoregulatory protein that is a key player in the innate immune response. Given its overexpression at sites of inflammation and in diseases marked by increasingly oxidative environments,… read more here.
Keywords: redox dependent; redox; macrophage migration; inhibitory factor ... See more keywords
A redox-dependent switch governing sensory axon degeneration and regeneration
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-23035-6
Abstract: Zebrafish (Danio rerio) fin amputation is a widely used model for studying sensory axon degeneration and regeneration. After injury, sensory neuron terminals rapidly degenerate before regenerating. While reactive oxygen species (ROS), particularly hydrogen peroxide (H₂O₂),… read more here.
Keywords: redox dependent; sensory axon; degeneration; axon degeneration ... See more keywords
Redox-dependent gating of VDAC by mitoNEET
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1908271116
Abstract: Significance This work demonstrates that the outer mitochondrial-anchored [2Fe-2S] mitoNEET is able to bind within the central cavity of the voltage-dependent anion channel (VDAC) and regulate its gating in a redox-dependent manner. These findings have… read more here.
Keywords: mitoneet; mitoneet redox; vdac; outer mitochondrial ... See more keywords
Activation of the UPR sensor ATF6α is regulated by its redox-dependent dimerization and ER retention by ERp18
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2122657119
Abstract: Significance Membrane and secretory proteins are synthesized in the endoplasmic reticulum (ER). Perturbations to ER function disrupts protein folding, causing misfolded proteins to accumulate, a condition known as ER stress. Cells adapt to stress by… read more here.
Keywords: dimerization; retention; redox dependent; activation upr ... See more keywords
Redox-dependent control of nuclear transcription in plants.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of experimental botany"
DOI: 10.1093/jxb/ery130
Abstract: Redox-dependent regulatory networks are affected by altered cellular or extracellular levels of reactive oxygen species (ROS). Perturbations of ROS production and scavenging homeostasis have a considerable impact on the nuclear transcriptome. While the regulatory mechanisms… read more here.
Keywords: transcription; nuclear transcription; control nuclear; dependent control ... See more keywords
Redox-dependent condensation and cytoplasmic granulation by human ssDNA-binding protein-1 delineate roles in oxidative stress response
Sign Up to like & getrecommendations! Published in 2024 at "iScience"
DOI: 10.1101/2023.07.25.550517
Abstract: Human single-stranded DNA binding protein 1 (hSSB1/NABP2/OBFC2B) plays central roles in the repair of DNA breaks and oxidized DNA lesions. Here we show that hSSB1 undergoes liquid-liquid phase separation (LLPS) that is redox-dependent and requires… read more here.
Keywords: redox dependent; stress; oxidative stress; response ... See more keywords
SAXS Examinations of the Redox-Dependent Formation of a DNA-SOD1 Complex
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232012673
Abstract: Cu/Zn superoxide dismutase (SOD1) plays a key role in the maintenance of cellular reactive oxygen species (ROS) homeostasis as an antioxidant enzyme. We recently found that SOD1 is involved in the regulation of gene expression… read more here.
Keywords: redox dependent; dependent formation; dna; formation dna ... See more keywords