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Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.10.161
Abstract: Evidence over the years has highlighted the importance of intracellular redox status in determining cell fate. To date, our work has shown that a pro-oxidant intracellular milieu, particularly a mild increase in superoxide (O2•‒) promotes…
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Keywords:
superoxide;
activation;
cancer;
redox dependent ... See more keywords
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Published in 2019 at "Redox Biology"
DOI: 10.1016/j.redox.2019.101178
Abstract: Thioredoxins (TRX) are traditionally considered as enzymes catalyzing redox reactions. However, redox-independent functions of thioredoxins have been described in different organisms, although the underlying molecular mechanisms are yet unknown. We report here the characterization of…
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Keywords:
redox independent;
redox;
independent functions;
caenorhabditis elegans ... See more keywords
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Published in 2022 at "Structure"
DOI: 10.1016/j.str.2022.03.007
Abstract: Macrophage migration inhibitory factor (MIF) is a multifunctional immunoregulatory protein that is a key player in the innate immune response. Given its overexpression at sites of inflammation and in diseases marked by increasingly oxidative environments,…
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Keywords:
redox dependent;
redox;
macrophage migration;
inhibitory factor ... See more keywords
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Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1908271116
Abstract: Significance This work demonstrates that the outer mitochondrial-anchored [2Fe-2S] mitoNEET is able to bind within the central cavity of the voltage-dependent anion channel (VDAC) and regulate its gating in a redox-dependent manner. These findings have…
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Keywords:
mitoneet;
mitoneet redox;
vdac;
outer mitochondrial ... See more keywords
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Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2122657119
Abstract: Significance Membrane and secretory proteins are synthesized in the endoplasmic reticulum (ER). Perturbations to ER function disrupts protein folding, causing misfolded proteins to accumulate, a condition known as ER stress. Cells adapt to stress by…
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Keywords:
dimerization;
retention;
redox dependent;
activation upr ... See more keywords
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Published in 2018 at "Journal of experimental botany"
DOI: 10.1093/jxb/ery130
Abstract: Redox-dependent regulatory networks are affected by altered cellular or extracellular levels of reactive oxygen species (ROS). Perturbations of ROS production and scavenging homeostasis have a considerable impact on the nuclear transcriptome. While the regulatory mechanisms…
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Keywords:
transcription;
nuclear transcription;
control nuclear;
dependent control ... See more keywords
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Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232012673
Abstract: Cu/Zn superoxide dismutase (SOD1) plays a key role in the maintenance of cellular reactive oxygen species (ROS) homeostasis as an antioxidant enzyme. We recently found that SOD1 is involved in the regulation of gene expression…
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Keywords:
redox dependent;
dependent formation;
dna;
formation dna ... See more keywords