Redox Dyshomeostasis with Dual Stimuli‐Activatable Dihydroartemisinin Nanoparticles to Potentiate Ferroptotic Therapy of Pancreatic Cancer
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DOI: 10.1002/smtd.202200888
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is highly lethal and resistant to conventional therapies, including chemo‐, radio‐, and immunotherapy. In this study, it is first determined that a combination of dihydroartemisinin (DHA) and RSL‐3 (a glutathione peroxidase… read more here.
Keywords: tumor cells; therapy; redox dyshomeostasis; dha ... See more keywords
Redox dyshomeostasis strategy for tumor therapy based on nanomaterials chemistry
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Science"
DOI: 10.1039/d1sc06315d
Abstract: Redox homeostasis, as an innate cellular defense mechanism, not only contributes to malignant transformation and metastasis of tumors, but also seriously restricts reactive oxygen species (ROS)-mediated tumor therapies, such as chemotherapy, radiotherapy, photodynamic therapy (PDT),… read more here.
Keywords: tumor therapy; chemistry; therapy; redox dyshomeostasis ... See more keywords