A Rational Foundation for Micheliolide-based Combination Strategy by Targeting Redox and Metabolic Circuit in Cancer Cells.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2022.115037
Abstract: Accumulating evidence has supported that targeting oxidative stress and metabolic alterations of cancer is an effective strategy to combat cancer. We previously reported that Dimethylaminomicheliolide (DMAMCL) and its active metabolite micheliolide (MCL) can cause oxidative… read more here.
Keywords: cancer cells; cancer; targeting redox; redox metabolic ... See more keywords
Mitochondrial function and autophagy: integrating proteotoxic, redox, and metabolic stress in Parkinson's disease
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DOI: 10.1111/jnc.14308
Abstract: Parkinson's disease (PD) is a movement disorder with widespread neurodegeneration in the brain. Significant oxidative, reductive, metabolic, and proteotoxic alterations have been observed in PD postmortem brains. The alterations of mitochondrial function resulting in decreased… read more here.
Keywords: redox metabolic; mitochondrial function; metabolic stress; proteotoxic redox ... See more keywords
Redox and Metabolic Regulation of Intestinal Barrier Function and Associated Disorders
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DOI: 10.3390/ijms232214463
Abstract: The intestinal epithelium forms a physical barrier assembled by intercellular junctions, preventing luminal pathogens and toxins from crossing it. The integrity of tight junctions is critical for maintaining intestinal health as the breakdown of tight… read more here.
Keywords: metabolic regulation; intestinal barrier; barrier; disorders redox ... See more keywords