Biological Evaluation and X‐ray Co‐crystal Structures of Cyclohexylpyrrolidine Ligands for Trypanothione Reductase, an Enzyme from the Redox Metabolism of Trypanosoma
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DOI: 10.1002/cmdc.201800067
Abstract: The tropical diseases human African trypanosomiasis, Chagas disease, and the various forms of leishmaniasis are caused by parasites of the family of trypanosomatids. These protozoa possess a unique redox metabolism based on trypanothione and trypanothione… read more here.
Keywords: reductase; crystal structures; ray crystal; trypanothione reductase ... See more keywords
Redox metabolism modulation as a mechanism in SSRI toxicity and pharmacological effects
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DOI: 10.1007/s00204-020-02721-6
Abstract: Depressive disorders are amongst the greatest mental health challenges, with an increasing number of patients being diagnosed each year. Though it has not yet been fully elucidated, redox metabolism imbalances and oxidative stress seem to… read more here.
Keywords: toxicity pharmacological; metabolism; pharmacological effects; redox metabolism ... See more keywords
In Vitro Modulation of Redox and Metabolism Interplay at the Brain Vascular Endothelium: Genomic and Proteomic Profiles of Sulforaphane Activity
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DOI: 10.1038/s41598-018-31137-7
Abstract: Sulforaphane (SFN) has been shown to protect the brain vascular system and effectively reduce ischemic injuries and cognitive deficits. Given the robust cerebrovascular protection afforded by SFN, the objective of this study was to profile… read more here.
Keywords: brain vascular; metabolism; activity; brain ... See more keywords
Redox metabolism maintains the leukemogenic capacity and drug resistance of AML cells
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DOI: 10.1073/pnas.2210796120
Abstract: Significance By using the H2O2 sensor (termed as HyPerion), we unravel a unique redox metabolic preference in maintaining the reactive oxygen species (ROS) level of acute myeloid leukemia (AML) cells. HyPerion-low AML cells have enhanced… read more here.
Keywords: aml; redox metabolism; aml cells; drug resistance ... See more keywords
Recent Advances in Cellular Signaling Interplay between Redox Metabolism and Autophagy Modulation in Cancer: An Overview of Molecular Mechanisms and Therapeutic Interventions
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DOI: 10.3390/antiox12020428
Abstract: Autophagy is a fundamental homeostatic process in which certain cellular components are ingested by double-membrane autophagosomes and then degraded to create energy or to maintain cellular homeostasis and survival. It is typically observed in nutrient-deprived… read more here.
Keywords: cancer; redox metabolism; autophagy modulation; oxidative stress ... See more keywords
Cellular Redox Metabolism Is Modulated by the Distinct Localization of Cyclic Nucleotide Phosphodiesterase 5A Isoforms
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DOI: 10.3390/ijms23158587
Abstract: 3’-5’ cyclic nucleotide phosphodiesterases (PDEs) are a family of evolutionary conserved cAMP and/or cGMP hydrolysing enzymes, components of transduction pathways regulating crucial aspects of cell life. Among them, cGMP-specific PDE5, being a regulator of vascular… read more here.
Keywords: metabolism modulated; localization; redox metabolism; cellular redox ... See more keywords
Influence of Schumann Range Electromagnetic Fields on Components of Plant Redox Metabolism in Wheat and Peas
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DOI: 10.3390/plants11151955
Abstract: The Schumann Resonances (ScR) are Extremely Low Frequency (ELF) electromagnetic resonances in the Earth-ionosphere cavity excited by global lightning discharges. ScR are the part of electromagnetic field (EMF) of Earth. The influence of ScR on… read more here.
Keywords: wheat; redox metabolism; influence; plant ... See more keywords