Rh(III)-Catalyzed Redox-Neutral [4+2] Annulation for Direct Assembly of 3-Acyl Isoquinolin-1(2H)-ones as Potent Antitumor Agents.
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DOI: 10.1002/cplu.201900616
Abstract: By virtue of an efficient rhodium(III)-catalyzed redox-neutral C-H activation/ring-opening of a strained ring/[4+2] annulation cascade of N-methoxybenzamides with propargyl cycloalkanols, diverse 3-acyl isoquinolin-1(2H)-ones were directly obtained in good yields and with excellent functional group compatibility.… read more here.
Keywords: annulation; iii catalyzed; redox neutral; isoquinolin ones ... See more keywords
Redox-Neutral Transformations of Carbon Dioxide Using Coordinatively Unsaturated Late Metal Silyl Amide Complexes.
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DOI: 10.1021/acs.inorgchem.2c03453
Abstract: Two-coordinate silylamido complexes of nickel and copper rapidly react with CO2 to selectively form a new cyanate ligand along with hexamethyldisiloxane byproducts. Mechanistic insight into these reactions was obtained from the synthesis of proposed intermediates,… read more here.
Keywords: carbon dioxide; dioxide using; neutral transformations; redox neutral ... See more keywords
Redox Neutral Radical-Relay Cobalt Catalysis toward C-H Fluorination and Amination.
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DOI: 10.1021/acs.orglett.0c01072
Abstract: A redox neutral radical-relay cobalt-catalyzed intramolecular C-H fluorination of N-fluoroamides featuring the in situ formed cobalt fluorides as the latent radical fluorinating agents is reported. Moreover, the reactivity of such a cobalt catalysis could be… read more here.
Keywords: cobalt; fluorination; redox neutral; neutral radical ... See more keywords
Redox-Neutral P(O)-N Coupling between P(O)-H Compounds and Azides via Dual Copper and Photoredox Catalysis.
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DOI: 10.1021/acs.orglett.0c02207
Abstract: We report a redox-neutral P(O)-N coupling reaction of P(O)-H compounds with azides via photoredox and copper catalysis, providing new access to useful phosphinamides, phosphonamides, and phosphoramides. This transformation tolerates a wide range of nucleophilic functionalities… read more here.
Keywords: neutral coupling; azides via; copper; compounds azides ... See more keywords
Redox-Neutral Generation of Iminyl Radicals by N-Heterocyclic Carbene Catalysis: Rapid Access to Phenanthridines from Vinyl Azides.
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DOI: 10.1021/acs.orglett.2c02118
Abstract: An N-heterocyclic carbene-catalyzed oxidant-, metal- and light-free iminyl radical generation pathway stemming from the reaction of vinyl azide and α-bromo ester is uncovered. This newly developed methodology is successfully applied to the redox-neutral construction of… read more here.
Keywords: redox neutral; generation iminyl; neutral generation; heterocyclic carbene ... See more keywords
A Metal-Free and Redox-Neutral Benzylic C-O Cyclization for Succinct Access of Helical Chromenes.
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DOI: 10.1021/acs.orglett.2c02728
Abstract: A redox-neutral benzylic C-O cyclization under beneficial transition-metal-free conditions is reported. Key to the success of this process is the utilization of the Tf anion as the leaving group for achieving the redox-neutral transformation. This… read more here.
Keywords: metal free; helical chromenes; benzylic cyclization; cyclization ... See more keywords
Redox-Neutral Ruthenium(II)-Catalyzed Enol-Directed Arene C-H Alkylation with Maleimides.
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DOI: 10.1021/acs.orglett.2c03858
Abstract: An enol-assisted regioselective arene C-H alkylation with maleimides is developed under redox-neutral ruthenium(II) catalysis, offering a wide variety of valuable 3-aryl succinimides including amino acid embedded frameworks in good to excellent yields. The products were… read more here.
Keywords: redox neutral; alkylation maleimides; neutral ruthenium; arene alkylation ... See more keywords
Redox-Neutral 1,4-Dicarbonfunctionalization of 1,3-Butadiene by Merging Photoredox and Nickel Catalysis.
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DOI: 10.1021/acs.orglett.2c04060
Abstract: The diverse functionalization of 1,3-butadiene provides wide applicability toward the synthesis of abundant and useful allylic compounds. Here, we describe a three-component and redox-neutral assembly of readily available C═X compounds, 1,3-butadiene, and various nucleophiles by… read more here.
Keywords: butadiene; nickel catalysis; merging photoredox; photoredox nickel ... See more keywords
Photoredox-Catalyzed Redox-Neutral Decarboxylative C-H Acylations of Coumarins with α-Keto Acid.
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DOI: 10.1021/acs.orglett.3c00632
Abstract: A novel and green photocatalytic strategy for the synthesis of C-4-acylated coumarins with α-keto acids and 3-nitrocoumarin has been developed. This operationally simple protocol works under mild reaction conditions, providing convenient access to 4-acyl coumarin… read more here.
Keywords: coumarins keto; decarboxylative acylations; neutral decarboxylative; redox neutral ... See more keywords
Redox-Neutral Synthesis of Sulfilimines through the S-Alkylation of Sulfenamides.
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DOI: 10.1021/acs.orglett.3c01060
Abstract: In this work, we developed a metal-free and redox-neutral strategy for the selective S-alkylation of sulfenamides under basic conditions to yield sulfilimines. The key step involves the resonance between bivalent nitrogen-centered anions, generated after deprotonation… read more here.
Keywords: neutral synthesis; synthesis sulfilimines; alkylation sulfenamides; alkylation ... See more keywords
Redox-Neutral Strategy for Sulfilimines Synthesis via S-Arylation of Sulfenamides.
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DOI: 10.1021/acs.orglett.3c01077
Abstract: In this investigation, an unprecedented transition-metal-free and redox-neutral synthesis of sulfilimines was realized through the S-arylation of readily obtainable sulfenamides employing diaryliodonium salts. The pivotal step encompassed the resonance between bivalent nitrogen-centered anions, engendered postdeprotonation… read more here.
Keywords: neutral strategy; synthesis; strategy sulfilimines; arylation ... See more keywords