Effects of Alternative Redox Partners and Oxidizing Agents on CYP154C8 Catalytic Activity and Product Distribution
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DOI: 10.1002/cbic.201800284
Abstract: CYP154C8 catalyzes the hydroxylation of diverse steroids, as has previously been demonstrated, by using an NADH‐dependent system including putidaredoxin and putidaredoxin reductase as redox partner proteins carrying electrons from NADH. In other reactions, CYP154C8 reconstituted… read more here.
Keywords: alternative redox; redox partners; partners oxidizing; product distribution ... See more keywords
Evolution of Cytochrome P450 Enzymes and Their Redox Partners in Archaea
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DOI: 10.3390/ijms24044161
Abstract: Cytochrome P450 monooxygenases (CYPs/P450s) and their redox partners, ferredoxins, are ubiquitous in organisms. P450s have been studied in biology for over six decades owing to their distinct catalytic activities, including their role in drug metabolism.… read more here.
Keywords: redox partners; cytochrome p450; p450 enzymes; evolution cytochrome ... See more keywords
Characterization of Gel16 as a Cytochrome P450 in Geldanamycin Biosynthesis and in-silico Analysis for an Endogenous Electron Transport System.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of microbiology and biotechnology"
DOI: 10.4014/jmb.1809.09008
Abstract: Geldanamycin and its derivatives, inhibitors of heat shock protein 90, are considered potent anticancer drugs, although their biosynthetic pathways have not yet been fully elucidated. The key step of conversion of 4,5-dihydrogeldanamycin to geldanamycin was… read more here.
Keywords: cytochrome p450; geldanamycin; redox partners; characterization gel16 ... See more keywords