Redox-Selective Iron Catalysis for α-Amino C-H Bond Functionalization via Aerobic Oxidation.
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DOI: 10.1021/acs.orglett.9b03542
Abstract: Single-electron oxidation and α-deprotonation of tertiary anilines using Fe(phen)3(PF6)3 afford α-aminoalkyl radicals, which can be coupled with electrophilic partners to afford various tetrahydroquinolines. Mechanistically, the Fe(phen)n2+/3+ catalytic cycle is maintained by O2 or a TBHP… read more here.
Keywords: iron catalysis; oxidation; redox selective; iron ... See more keywords