Redox signalling in physiology, ageing and disease
Sign Up to like & getrecommendations! Published in 2020 at "Biogerontology"
DOI: 10.1007/s10522-020-09885-9
Abstract: Ageing is a natural phenomenon associated with deterioration in function of multiple tissues. Whilst lifespan increased in the recent years, this has not been concomitant with an increase in healthspan—the average number of years spent… read more here.
Keywords: redox signalling; redox; ageing disease; physiology ... See more keywords
Diurnal oscillations of endogenous H2O2 sustained by p66Shc regulate circadian clocks
Sign Up to like & getrecommendations! Published in 2019 at "Nature Cell Biology"
DOI: 10.1038/s41556-019-0420-4
Abstract: Redox balance, an essential feature of healthy physiological steady states, is regulated by circadian clocks, but whether or how endogenous redox signalling conversely regulates clockworks in mammals remains unknown. Here, we report circadian rhythms in… read more here.
Keywords: redox signalling; endogenous h2o2; circadian clocks; h2o2 ... See more keywords
Pro‐survival redox signalling in progesterone‐mediated retinal neuroprotection
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Neuroscience"
DOI: 10.1111/ejn.13604
Abstract: Retinitis pigmentosa (RP) is a group of hereditary retinal diseases, characterised by photoreceptor cell loss. Despite a substantial understanding of the mechanisms leading to cell death, an effective therapeutic strategy is sought. Our laboratory has… read more here.
Keywords: pro survival; redox signalling; survival redox; progesterone ... See more keywords
Membrane raft redox signalling contributes to endothelial dysfunction and vascular remodelling of thoracic aorta in angiotensin II‐infused rats
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Physiology"
DOI: 10.1113/ep087335
Abstract: What is the central question of this study? Is the membrane raft redox signalling pathway involved in blood pressure increase, endothelial dysfunction and vascular remodelling in an angiotensin II‐induced hypertensive animal model? What is the… read more here.
Keywords: redox signalling; membrane raft; endothelial dysfunction; raft redox ... See more keywords
Modulating Tumour Hypoxia in Prostate Cancer Through Exercise: The Impact of Redox Signalling on Radiosensitivity
Sign Up to like & getrecommendations! Published in 2022 at "Sports Medicine - Open"
DOI: 10.1186/s40798-022-00436-9
Abstract: Prostate cancer is a complex disease affecting millions of men globally. Radiotherapy (RT) is a common treatment modality although treatment efficacy is dependent upon several features within the tumour microenvironment (TME), especially hypoxia. A hypoxic… read more here.
Keywords: treatment; tumour hypoxia; prostate cancer; redox signalling ... See more keywords
Patient Endothelial Colony-Forming Cells to Model Coronary Artery Disease Susceptibility and Unravel the Role of Dysregulated Mitochondrial Redox Signalling
Sign Up to like & getrecommendations! Published in 2021 at "Antioxidants"
DOI: 10.3390/antiox10101547
Abstract: Mechanisms involved in the individual susceptibility to atherosclerotic coronary artery disease (CAD) beyond traditional risk factors are poorly understood. Here, we describe the utility of cultured patient-derived endothelial colony-forming cells (ECFCs) in examining novel mechanisms… read more here.
Keywords: redox signalling; susceptibility; coronary artery; endothelial colony ... See more keywords
Computational Models on Pathological Redox Signalling Driven by Pregnancy: A Review
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11030585
Abstract: Oxidative stress is associated with a myriad of diseases including pregnancy pathologies with long-term cardiovascular repercussions for both the mother and baby. Aberrant redox signalling coupled with deficient antioxidant defence leads to chronic molecular impairment.… read more here.
Keywords: review; computational models; redox; pregnancy ... See more keywords
How the Disruption of Mitochondrial Redox Signalling Contributes to Ageing
Sign Up to like & getrecommendations! Published in 2023 at "Antioxidants"
DOI: 10.3390/antiox12040831
Abstract: In the past, mitochondrial reactive oxygen species (mtROS) were considered a byproduct of cellular metabolism. Due to the capacity of mtROS to cause oxidative damage, they were proposed as the main drivers of ageing and… read more here.
Keywords: mitochondrial redox; disruption mitochondrial; contributes ageing; redox signalling ... See more keywords
Roles of Autophagy in Oxidative Stress
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21093289
Abstract: Autophagy is a catabolic process for unnecessary or dysfunctional cytoplasmic contents by lysosomal degradation pathways. Autophagy is implicated in various biological processes such as programmed cell death, stress responses, elimination of damaged organelles and development.… read more here.
Keywords: redox signalling; redox; roles autophagy; stress ... See more keywords
Implications of SGLT Inhibition on Redox Signalling in Atrial Fibrillation
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22115937
Abstract: Atrial fibrillation (AF) is the most common sustained (atrial) arrhythmia, a considerable global health burden and often associated with heart failure. Perturbations of redox signalling in cardiomyocytes provide a cellular substrate for the manifestation and… read more here.
Keywords: atrial fibrillation; redox signalling; heart failure;