Discovery and Synthesis of a Pyrimidine-Based Aurora Kinase Inhibitor to Reduce Levels of MYC Oncoproteins
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DOI: 10.1021/acs.jmedchem.0c01806
Abstract: The A-type Aurora kinase is upregulated in many human cancers, and it stabilizes MYC-family oncoproteins, which have long been considered an undruggable target. Here, we describe the design and synthesis of a series of pyrimidine-based… read more here.
Keywords: reduce levels; kinase; pyrimidine based; aurora kinase ... See more keywords
Recent advances in arsenic mitigation in rice through biotechnological approaches
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Phytoremediation"
DOI: 10.1080/15226514.2022.2080803
Abstract: Abstract Arsenic (As) is a major threat to the environment and human health due to its toxicity and carcinogenicity. Occurrence of alarming concentrations of As in water and soil leads to its bioaccumulation in crops… read more here.
Keywords: arsenic mitigation; reduce levels; rice; levels rice ... See more keywords