Epiregulin (EREG) is upregulated through an IL‐1β autocrine loop in Caco‐2 epithelial cells with reduced CFTR function
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DOI: 10.1002/jcb.26483
Abstract: CFTR is a cAMP‐regulated chloride channel, whose mutations produce cystic fibrosis. The impairment of CFTR activity increases the intracellular Cl− concentration, which in turn produces an increased interleukin‐1β (IL‐1β) secretion. The secreted IL‐1β then induces… read more here.
Keywords: ereg; epiregulin ereg; autocrine loop; reduced cftr ... See more keywords