Reduced expression of annexin A1 promotes gemcitabine and 5-fluorouracil drug resistance of human pancreatic cancer
Sign Up to like & getrecommendations! Published in 2019 at "Investigational New Drugs"
DOI: 10.1007/s10637-019-00785-5
Abstract: Intrinsic chemoresistance is the main reason for the failure of human pancreatic ductal adenocarcinoma (PDAC) therapy. To identify the candidate protein, we compared the protein expression profiling of PDAC cells and its distinct surviving cells… read more here.
Keywords: expression annexin; reduced expression; drug; human pancreatic ... See more keywords
Reduced expression of Ecdysone induced early gene, E93: A saviour for Drosophila Malpighian tubules
Sign Up to like & getrecommendations! Published in 2017 at "Mechanisms of Development"
DOI: 10.1016/j.mod.2017.04.236
Abstract: formation and disassembly of granules and that 2) the mechanisms differ in details. Ectopic expression of Emi2-GFP in meiosis I caused arrest of meiotic cell cycle at metaphase I through inhibition of APC/C activity. Together,… read more here.
Keywords: induced early; reduced expression; ecdysone induced; early gene ... See more keywords
Reduced expression of PARK2 in manganese‐exposed smelting workers
Sign Up to like & getrecommendations! Published in 2017 at "Neurotoxicology"
DOI: 10.1016/j.neuro.2017.08.006
Abstract: HIGHLIGHTSEffect of Mn exposure on PARK2 gene expression among smelters was studied.Cumulative Mn exposure was significantly higher in smelters than controls.Expression of PARK2 mRNA in smelters was decreased by 42% compared to controls.Expression of PARK2… read more here.
Keywords: park2; reduced expression; expression park2; cumulative exposure ... See more keywords
Functional impact of subunit composition and compensation on Drosophila melanogaster nicotinic receptors–targets of neonicotinoids
Sign Up to like & getrecommendations! Published in 2023 at "PLOS Genetics"
DOI: 10.1371/journal.pgen.1010522
Abstract: Neonicotinoid insecticides target insect nicotinic acetylcholine receptors (nAChRs) and their adverse effects on non-target insects are of serious concern. We recently found that cofactor TMX3 enables robust functional expression of insect nAChRs in Xenopus laevis… read more here.
Keywords: reduced expression; subunit; drosophila melanogaster; expression ... See more keywords
Loss of SMAD4 Is Associated With Poor Tumor Immunogenicity and Reduced PD-L1 Expression in Pancreatic Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.806963
Abstract: Transforming Growth Factor β (TGFβ) is a key mediator of immune evasion in pancreatic ductal adenocarcinoma (PDAC), and the addition of TGFβ inhibitors in select immunotherapy regimens shows early promise. Though the TGFβ target SMAD4… read more here.
Keywords: loss smad4; tumor; reduced expression; smad4 ... See more keywords
Characteristics of Cellulose Nanofibrils from Transgenic Trees with Reduced Expression of Cellulose Synthase Interacting 1
Sign Up to like & getrecommendations! Published in 2022 at "Nanomaterials"
DOI: 10.3390/nano12193448
Abstract: Cellulose nanofibrils can be derived from the native load-bearing cellulose microfibrils in wood. These microfibrils are synthesized by a cellulose synthase enzyme complex that resides in the plasma membrane of developing wood cells. It was… read more here.
Keywords: trees reduced; expression; cellulose nanofibrils; wood ... See more keywords