Reduced-intensity allogeneic hematopoietic stem cell transplantation combined with imatinib has comparable event-free survival and overall survival to long-term imatinib treatment in young patients with chronic myeloid leukemia
Sign Up to like & getrecommendations! Published in 2017 at "Annals of Hematology"
DOI: 10.1007/s00277-017-3021-y
Abstract: The relative merits of reduced intensity hematopoietic stem cell transplantation (RIST) for chronic myeloid leukemia (CML) in the first chronic phase (CP) in imatinib era have not been evaluated. The study was designed to compare… read more here.
Keywords: treatment; rist; reduced intensity; hematopoietic stem ... See more keywords
Reduced Intensity Conditioning for Allogeneic Hematopoietic Cell Transplantation Utilizing Cladribine and Melphalan
Sign Up to like & getrecommendations! Published in 2019 at "Biology of Blood and Marrow Transplantation"
DOI: 10.1016/j.bbmt.2018.12.786
Abstract: Introduction Reduced intensity conditioning (RIC) allogeneic hematopoietic cell transplantation (HCT) has been shown to be successful; however, the ideal RIC regimen is not known. In this study, we report the pooled results of three separate… read more here.
Keywords: reduced intensity; gvhd; transplantation; cell ... See more keywords
Comparing the Incidence of Thyroid Dysfunction in Pediatric Subjects after HSCT with Reduced Intensity Vs. Myeloablative Conditioning
Sign Up to like & getrecommendations! Published in 2020 at "Biology of Blood and Marrow Transplantation"
DOI: 10.1016/j.bbmt.2019.12.187
Abstract: Introduction Subjects who undergo hematopoietic stem cell transplant (HSCT) are at increased risk for thyroid dysfunction. Few studies compare myeloablative (MAC) and reduced intensity (RIC) conditioning regimens. Objectives Describe the prevalence, incidence, and risk factors… read more here.
Keywords: thyroid dysfunction; risk; hsct; reduced intensity ... See more keywords
Safety Profile and Efficacy of Cidofovir for Adenovirus in Pediatric Stem Cell Transplant Recipients Following Reduced-Intensity Conditioning
Sign Up to like & getrecommendations! Published in 2020 at "Biology of Blood and Marrow Transplantation"
DOI: 10.1016/j.bbmt.2019.12.311
Abstract: Background Adenovirus (ADV) infection remains a significant cause of morbidity and mortality following allogeneic hematopoietic stem cell transplantation (allo-HSCT), particularly in the pediatric population. Pre-emptive monitoring by polymerase chain reaction (PCR) assay for ADV viremia… read more here.
Keywords: intensity conditioning; treatment; cdv; pcr ... See more keywords
Long-term outcome analysis of reduced-intensity allogeneic stem cell transplantation in patients with mantle cell lymphoma: a retrospective study from the EBMT Lymphoma Working Party
Sign Up to like & getrecommendations! Published in 2018 at "Bone Marrow Transplantation"
DOI: 10.1038/s41409-017-0067-3
Abstract: Reduced-intensity allogeneic stem cell transplantation (RIST) is usually reserved for patients with mantle cell lymphoma who relapse after an autoSCT. However, the long-term efficacy of RIST and its curative potential have not been clearly demonstrated.… read more here.
Keywords: long term; intensity allogeneic; transplantation; reduced intensity ... See more keywords
Impaired thymopoiesis predicts for a high risk of severe infections after reduced intensity conditioning without anti-thymocyte globulin in double umbilical cord blood transplantation
Sign Up to like & getrecommendations! Published in 2018 at "Bone Marrow Transplantation"
DOI: 10.1038/s41409-018-0103-y
Abstract: Umbilical cord blood stem cell transplantation (UCBT) is associated with retarded hematopoietic recovery and immune reconstitution and a high infection-related morbidity and mortality, especially after conditioning including anti-thymocyte globulin (ATG). However, data on immune recovery,… read more here.
Keywords: anti thymocyte; cord blood; thymocyte globulin; umbilical cord ... See more keywords
Lentiviral globin gene therapy with reduced-intensity conditioning in adults with β-thalassemia: a phase 1 trial
Sign Up to like & getrecommendations! Published in 2022 at "Nature Medicine"
DOI: 10.1038/s41591-021-01554-9
Abstract: β-Thalassemias are inherited anemias that are caused by the absent or insufficient production of the β chain of hemoglobin. Here we report 6–8-year follow-up of four adult patients with transfusion-dependent β-thalassemia who were infused with… read more here.
Keywords: reduced intensity; intensity conditioning; lentiviral globin; globin ... See more keywords
Successful Umbilical Cord Blood Transplantation With Reduced-intensity Conditioning for Acute Myeloid Leukemia in a Child With Shwachman-Diamond Syndrome.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Pediatric Hematology/Oncology"
DOI: 10.1097/mph.0000000000001773
Abstract: Outcomes of patients with Shwachman-Diamond syndrome (SDS) who developed myeloid malignancies are poor because of refractory disease and high hematopoietic stem cell transplantation-related mortality. We herein report a case of a 7-year-old girl with SDS… read more here.
Keywords: myeloid leukemia; acute myeloid; reduced intensity; transplantation ... See more keywords
The effect of donor type on outcomes in adults with acute myeloid leukemia after reduced‐intensity hematopoietic peripheral blood cell transplant – a retrospective study
Sign Up to like & getrecommendations! Published in 2020 at "Transplant International"
DOI: 10.1111/tri.13659
Abstract: We retrospectively analyzed outcomes in patients with acute myeloid leukemia (AML) receiving reduced‐intensity conditioning (RIC) hematopoietic stem cell transplants (HCT) from a peripheral blood (PB) source. We identified 46 haploidentical HCT (haplo), 59 matched unrelated… read more here.
Keywords: myeloid leukemia; donor; reduced intensity; peripheral blood ... See more keywords
ALL-RIC trial protocol: a comparison of reduced dose total body irradiation (TBI) and cyclophosphamide with fludarabine and melphalan reduced intensity conditioning in adults with acute lymphoblastic leukaemia (ALL) in complete remission.
Sign Up to like & getrecommendations! Published in 2023 at "BMJ open"
DOI: 10.1136/bmjopen-2022-067790
Abstract: Introduction The usage of a T-cell depleted, reduced intensity conditioning (RIC) approach to haematopoietic cell transplantation (HCT) in adult patients with acute lymphoblastic leukaemia (ALL) over 40 years of age and in first complete remission… read more here.
Keywords: intensity conditioning; conditioning; trial; reduced intensity ... See more keywords
Myeloablative vs reduced intensity T-cell-replete haploidentical transplantation for hematologic malignancy.
Sign Up to like & getrecommendations! Published in 2019 at "Blood advances"
DOI: 10.1182/bloodadvances.2019000627
Abstract: In the absence of prospective studies that examine the effect of conditioning regimen intensity after T-cell-replete haploidentical transplant for acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), and myelodysplastic syndrome (MDS), a retrospective cohort analysis… read more here.
Keywords: cell replete; replete haploidentical; intensity; regimen intensity ... See more keywords