Reduced-intensity allogeneic hematopoietic stem cell transplantation combined with imatinib has comparable event-free survival and overall survival to long-term imatinib treatment in young patients with chronic myeloid leukemia
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DOI: 10.1007/s00277-017-3021-y
Abstract: The relative merits of reduced intensity hematopoietic stem cell transplantation (RIST) for chronic myeloid leukemia (CML) in the first chronic phase (CP) in imatinib era have not been evaluated. The study was designed to compare… read more here.
Keywords: treatment; rist; reduced intensity; hematopoietic stem ... See more keywords
Reduced Intensity Conditioning for Allogeneic Hematopoietic Cell Transplantation Utilizing Cladribine and Melphalan
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DOI: 10.1016/j.bbmt.2018.12.786
Abstract: Introduction Reduced intensity conditioning (RIC) allogeneic hematopoietic cell transplantation (HCT) has been shown to be successful; however, the ideal RIC regimen is not known. In this study, we report the pooled results of three separate… read more here.
Keywords: reduced intensity; gvhd; transplantation; cell ... See more keywords
Comparing the Incidence of Thyroid Dysfunction in Pediatric Subjects after HSCT with Reduced Intensity Vs. Myeloablative Conditioning
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DOI: 10.1016/j.bbmt.2019.12.187
Abstract: Introduction Subjects who undergo hematopoietic stem cell transplant (HSCT) are at increased risk for thyroid dysfunction. Few studies compare myeloablative (MAC) and reduced intensity (RIC) conditioning regimens. Objectives Describe the prevalence, incidence, and risk factors… read more here.
Keywords: thyroid dysfunction; risk; hsct; reduced intensity ... See more keywords
Safety Profile and Efficacy of Cidofovir for Adenovirus in Pediatric Stem Cell Transplant Recipients Following Reduced-Intensity Conditioning
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DOI: 10.1016/j.bbmt.2019.12.311
Abstract: Background Adenovirus (ADV) infection remains a significant cause of morbidity and mortality following allogeneic hematopoietic stem cell transplantation (allo-HSCT), particularly in the pediatric population. Pre-emptive monitoring by polymerase chain reaction (PCR) assay for ADV viremia… read more here.
Keywords: intensity conditioning; treatment; cdv; pcr ... See more keywords
Long-term outcome analysis of reduced-intensity allogeneic stem cell transplantation in patients with mantle cell lymphoma: a retrospective study from the EBMT Lymphoma Working Party
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DOI: 10.1038/s41409-017-0067-3
Abstract: Reduced-intensity allogeneic stem cell transplantation (RIST) is usually reserved for patients with mantle cell lymphoma who relapse after an autoSCT. However, the long-term efficacy of RIST and its curative potential have not been clearly demonstrated.… read more here.
Keywords: long term; intensity allogeneic; transplantation; reduced intensity ... See more keywords
Impaired thymopoiesis predicts for a high risk of severe infections after reduced intensity conditioning without anti-thymocyte globulin in double umbilical cord blood transplantation
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DOI: 10.1038/s41409-018-0103-y
Abstract: Umbilical cord blood stem cell transplantation (UCBT) is associated with retarded hematopoietic recovery and immune reconstitution and a high infection-related morbidity and mortality, especially after conditioning including anti-thymocyte globulin (ATG). However, data on immune recovery,… read more here.
Keywords: anti thymocyte; cord blood; thymocyte globulin; umbilical cord ... See more keywords
Lentiviral globin gene therapy with reduced-intensity conditioning in adults with β-thalassemia: a phase 1 trial
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DOI: 10.1038/s41591-021-01554-9
Abstract: β-Thalassemias are inherited anemias that are caused by the absent or insufficient production of the β chain of hemoglobin. Here we report 6–8-year follow-up of four adult patients with transfusion-dependent β-thalassemia who were infused with… read more here.
Keywords: reduced intensity; intensity conditioning; lentiviral globin; globin ... See more keywords
Impact of HLA eplets mismatch load on outcomes of outpatient haploidentical-related stem cell transplantation from peripheral blood after reduced intensity conditioning
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DOI: 10.1080/17474086.2025.2524522
Abstract: ABSTRACT Background Molecular typing before hematopoietic stem cell transplantation (HSCT) at the eplet level is an emerging method to optimize HLA matching. Materials and methods Patients who received outpatient haploidentical HSCT (Haplo-HSCT) from a sibling… read more here.
Keywords: cell transplantation; mes load; reduced intensity; hla ... See more keywords
Successful Umbilical Cord Blood Transplantation With Reduced-intensity Conditioning for Acute Myeloid Leukemia in a Child With Shwachman-Diamond Syndrome.
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DOI: 10.1097/mph.0000000000001773
Abstract: Outcomes of patients with Shwachman-Diamond syndrome (SDS) who developed myeloid malignancies are poor because of refractory disease and high hematopoietic stem cell transplantation-related mortality. We herein report a case of a 7-year-old girl with SDS… read more here.
Keywords: myeloid leukemia; acute myeloid; reduced intensity; transplantation ... See more keywords
Reduced‐intensity conditioning with fludarabine/busulfan versus fludarabine/low‐dose melphalan in patients with non‐Hodgkin lymphoma undergoing allogeneic haematopoietic stem cell transplantation
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DOI: 10.1111/bjh.19651
Abstract: Reduced‐intensity conditioning regimens are commonly used in allogeneic haematopoietic cell transplantation for non‐Hodgkin lymphoma (NHL); however, the optimal regimen remains unknown. In this study, the outcomes of adult patients with NHL who received fludarabine plus… read more here.
Keywords: allogeneic haematopoietic; year; cell transplantation; reduced intensity ... See more keywords
Allogeneic Haematopoietic Stem Cell Transplantation Using Reduced‐Intensity Fludarabine, Busulfan and Anti‐T‐Lymphocyte Globulin With Strategic Donor Lymphocyte Infusion in Older Patients With Myeloid Malignancy
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DOI: 10.1111/ejh.14417
Abstract: Fludarabine, busulfan, and anti‐T‐lymphocyte globulin (FLUBU3+ATLG) reduced‐intensity conditioning is an established preparative regimen for allogeneic haematopoietic stem cell transplantation in older patients with myeloid malignancy. We examined its modern‐day performance in 175 sequentially treated patients… read more here.
Keywords: fludarabine busulfan; reduced intensity; older patients; lymphocyte ... See more keywords