Simultaneous Pharmacokinetic Analysis of Nitrate and its Reduced Metabolite, Nitrite, Following Ingestion of Inorganic Nitrate in a Mixed Patient Population.
Sign Up to like & getrecommendations! Published in 2020 at "Pharmaceutical research"
DOI: 10.1007/s11095-020-02959-w
Abstract: PURPOSE The pharmacokinetic properties of plasma NO3- and its reduced metabolite, NO2-, have been separately described, but there has been no reported attempt to simultaneously model their pharmacokinetics following NO3- ingestion. This report describes development… read more here.
Keywords: simultaneous pharmacokinetic; model; nitrate; pharmacokinetic analysis ... See more keywords
The nitro-reduced metabolite of nimesulide: Crystal structure, spectroscopic characterization, ESI-QTOF mass spectrometric analysis and antibacterial evaluation
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DOI: 10.1016/j.molstruc.2017.12.085
Abstract: Abstract Here we present a synthetic procedure, spectroscopic characterization and single-crystal X-ray structure for the nitro-reduced metabolite of the anti-inflammatory drug nimesulide, hereby referred to as NMS-NH2. The nitro-reduced metabolite was synthesized using the Bechamp… read more here.
Keywords: spectroscopic characterization; nms nh2; nitro reduced; structure ... See more keywords