Blocking RpoN reduces virulence of Pseudomonas aeruginosa isolated from cystic fibrosis patients and increases antibiotic sensitivity in a laboratory strain
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-43060-6
Abstract: Multidrug-resistant organisms are increasing in healthcare settings, and there are few antimicrobials available to treat infections from these bacteria. Pseudomonas aeruginosa is an opportunistic pathogen in burn patients and individuals with cystic fibrosis (CF), and… read more here.
Keywords: cystic fibrosis; pseudomonas aeruginosa; virulence; reduces virulence ... See more keywords
A novel phenolic derivative inhibits AHL-dependent quorum sensing signaling in Pseudomonas aeruginosa
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.996871
Abstract: Increasing antibiotic resistance and the decline in the pharmaceutical industry’s investments have amplified the need for novel treatments for multidrug-resistant bacteria. Quorum sensing (QS) inhibitors reduce pathogens’ virulence without selective pressure on bacteria and provide… read more here.
Keywords: inhibits ahl; virulence; ahl dependent; quorum sensing ... See more keywords