Using Digestion by IdeS Protease to Improve Quantification of Degradants in Monoclonal Antibodies by Non-Reducing Capillary Gel Electrophoresis.
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DOI: 10.1021/acs.analchem.2c02630
Abstract: Monoclonal antibodies (mAbs) have become predominant therapeutics by providing highly specific mechanisms of action enabling treatment of complex diseases. However, mAbs themselves are highly complex and require thorough testing and characterization to ensure efficacy and… read more here.
Keywords: capillary gel; reducing cge; gel electrophoresis; non reducing ... See more keywords