Tolrestat acts atypically as a competitive inhibitor of the thermostable aldo‐keto reductase Tm1743 from Thermotoga maritima
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Letters"
DOI: 10.1002/1873-3468.13630
Abstract: Tolrestat and epalrestat have been characterized as noncompetitive inhibitors of aldo‐ketone reductase 1B1 (AKR1B1), a leading drug target for the treatment of type 2 diabetes complications. However, clinical applications are limited for most AKR1B1 inhibitors… read more here.
Keywords: reductase; thermotoga maritima; tm1743 thermotoga; tm1743 ... See more keywords
Aromatic Halogenation by Using Bifunctional Flavin Reductase–Halogenase Fusion Enzymes
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DOI: 10.1002/cbic.201700391
Abstract: The remarkable site selectivity and broad substrate scope of flavin‐dependent halogenases (FDHs) has led to much interest in their potential as biocatalysts. Multiple engineering efforts have demonstrated that FDHs can be tuned for non‐native substrate… read more here.
Keywords: flavin reductase; using bifunctional; reductase; halogenation using ... See more keywords
Stabilization of the Reductase Domain in the Catalytically Self‐Sufficient Cytochrome P450BM3 by Consensus‐Guided Mutagenesis
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DOI: 10.1002/cbic.201700546
Abstract: The multidomain, catalytically self‐sufficient cytochrome P450 BM‐3 from Bacillus megaterium (P450BM3) constitutes a versatile enzyme for the oxyfunctionalization of organic molecules and natural products. However, the limited stability of the diflavin reductase domain limits the… read more here.
Keywords: p450bm3; mutagenesis; reductase; consensus ... See more keywords
Expanding the Biocatalytic Toolbox with a New Type of ene/yne‐Reductase from Cyclocybe aegerita
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DOI: 10.1002/cctc.202002011
Abstract: This study introduces a new type of ene/yne‐reductase from Cyclocybe aegerita with a broad substrate scope including aliphatic and aromatic alkenes/alkynes from which aliphatic C8‐alkenones, C8‐alkenals and aromatic nitroalkenes were the preferred substrates. By comparing… read more here.
Keywords: reduction; new type; reductase; type ene ... See more keywords
Biological Evaluation and X‐ray Co‐crystal Structures of Cyclohexylpyrrolidine Ligands for Trypanothione Reductase, an Enzyme from the Redox Metabolism of Trypanosoma
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DOI: 10.1002/cmdc.201800067
Abstract: The tropical diseases human African trypanosomiasis, Chagas disease, and the various forms of leishmaniasis are caused by parasites of the family of trypanosomatids. These protozoa possess a unique redox metabolism based on trypanothione and trypanothione… read more here.
Keywords: reductase; crystal structures; ray crystal; trypanothione reductase ... See more keywords
Detoxification of benzo[a]pyrene primarily depends on cytochrome P450, while bioactivation involves additional oxidoreductases including 5‐lipoxygenase, cyclooxygenase, and aldo‐keto reductase in the liver
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DOI: 10.1002/jbt.21902
Abstract: Cytochrome P450s are involved in detoxification and activation of benzo[a]pyrene (BaP) with unclear balance and unknown contribution of other oxidoreductases. Here, we investigated the BaP and BaP‐induced mutagenicity in hepatic and extra‐hepatic tissues using hepatic… read more here.
Keywords: reductase; gpt mice; detoxification; benzo pyrene ... See more keywords
Glyoxylate reductase/hydroxypyruvate reductase regulates the free d-aspartate level in mammalian cells.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cellular biochemistry"
DOI: 10.1002/jcb.30110
Abstract: Multiple d-amino acids are present in mammalian cells, and these compounds have distinctive physiological functions. Among the free d-amino acids identified in mammals, d-aspartate plays critical roles in the neuroendocrine and endocrine systems, as well… read more here.
Keywords: aspartate; reductase; reductase hydroxypyruvate; mammalian cells ... See more keywords
Imidazole and nitroimidazole derivatives as NADH‐fumarate reductase inhibitors: Density functional theory studies, homology modeling, and molecular docking
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DOI: 10.1002/jcc.26959
Abstract: Chagas disease is caused by Trypanosoma cruzi. Benznidazole and nifurtimox are drugs used for its therapy; nevertheless, they have collateral effects. NADH‐fumarate (FUM) reductase is a potential pharmacological target since it is essential for survival… read more here.
Keywords: fum reductase; nadh fum; nitroimidazole derivatives; imidazole nitroimidazole ... See more keywords
Not as easy as π: An insertional residue does not explain the π‐helix gain‐of‐function in two‐component FMN reductases
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DOI: 10.1002/pro.3504
Abstract: The π‐helix located at the tetramer interface of two‐component FMN‐dependent reductases contributes to the structural divergence from canonical FMN‐bound reductases within the NADPH:FMN reductase family. The π‐helix in the SsuE FMN‐dependent reductase of the alkanesulfonate… read more here.
Keywords: reductase; insertional residue; fmn; helix ... See more keywords
Measurement of S-Nitrosoglutathione Reductase Activity in Plants.
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DOI: 10.1007/978-1-4939-9790-9_5
Abstract: S-nitrosation as a redox-based posttranslational modification of protein cysteine has emerged as an integral part of signaling pathways of nitric oxide across all types of organisms. Protein S-nitrosation status is controlled by two key mechanisms:… read more here.
Keywords: activity plants; reductase; nitrosoglutathione reductase; measurement nitrosoglutathione ... See more keywords
The role of the thioredoxin/thioredoxin reductase system in the metabolic syndrome: towards a possible prognostic marker?
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DOI: 10.1007/s00018-018-2745-8
Abstract: Mammalian thioredoxin reductase (TrxR) is a selenoprotein with three existing isoenzymes (TrxR1, TrxR2, and TrxR3), which is found primarily intracellularly but also in extracellular fluids. The main substrate thioredoxin (Trx) is similarly found (as Trx1… read more here.
Keywords: thioredoxin reductase; system; reductase; thioredoxin ... See more keywords