Bifunctional Imine Reductase Cascades for the Synthesis of Saturated N-Heterocycles
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DOI: 10.1021/acscatal.4c03832
Abstract: Saturated N-heterocycles constitute a vital scaffold for pharmaceutical chemistry but are challenging to access synthetically, particularly asymmetrically. Here, we demonstrate how imine reductases can achieve annulation through tandem inter- and intramolecular reductive amination processes. Imine… read more here.
Keywords: bifunctional imine; imine reductase; saturated heterocycles; reductase cascades ... See more keywords