Fungal indole alkaloid biogenesis through evolution of a bifunctional reductase/Diels–Alderase
Sign Up to like & getrecommendations! Published in 2019 at "Nature Chemistry"
DOI: 10.1038/s41557-019-0326-6
Abstract: Prenylated indole alkaloids such as the calmodulin-inhibitory malbrancheamides and anthelmintic paraherquamides possess great structural diversity and pharmaceutical utility. Here, we report complete elucidation of the malbrancheamide biosynthetic pathway accomplished through complementary approaches. These include a… read more here.
Keywords: alkaloid biogenesis; diels alderase; fungal indole; reductase diels ... See more keywords