Association of Treatment With 5α-Reductase Inhibitors and Prostate Cancer Mortality Among Older Adults
Sign Up to like & getrecommendations! Published in 2019 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2019.13612
Abstract: This cohort study examines the association between use of 5α-reductase inhibitors and prostate cancer mortality among US Medicare beneficiaries. read more here.
Keywords: mortality among; prostate cancer; inhibitors prostate; association ... See more keywords
Association of 5α-Reductase Inhibitors With Dementia, Depression, and Suicide
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DOI: 10.1001/jamanetworkopen.2022.48135
Abstract: Key Points Question Are 5α-reductase inhibitors (5-ARIs), used for benign prostatic hyperplasia and androgenic alopecia, associated with an increased risk for all-cause dementia, Alzheimer disease, vascular dementia, depression, and suicide? Findings This register-based prospective cohort… read more here.
Keywords: dementia depression; depression; depression suicide; dementia ... See more keywords
A new series of hydrazones as small‐molecule aldose reductase inhibitors
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DOI: 10.1002/ardp.202200570
Abstract: In the search for small‐molecule aldose reductase (AR) inhibitors, new tetrazole‐hydrazone hybrids (1–15) were designed. An efficient procedure was employed for the synthesis of compounds 1–15. All hydrazones were subjected to an in vitro assay… read more here.
Keywords: small molecule; reductase inhibitors; aldose reductase; molecule aldose ... See more keywords
Safety of 5α-reductase inhibitors and spironolactone in breast cancer patients receiving endocrine therapies
Sign Up to like & getrecommendations! Published in 2018 at "Breast Cancer Research and Treatment"
DOI: 10.1007/s10549-018-4996-3
Abstract: PurposeTo provide dermatologists and oncologists with a foundation for practical understanding and uses of 5α-reductase inhibitors and spironolactone for breast cancer patients and survivors receiving endocrine therapies (ETs), including the effect of these treatments on… read more here.
Keywords: breast cancer; inhibitors spironolactone; cancer; cancer patients ... See more keywords
The risk of dementia with the use of 5 alpha reductase inhibitors
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the Neurological Sciences"
DOI: 10.1016/j.jns.2017.05.064
Abstract: INTRODUCTION There has been considerable interest in the interplay between testosterone and cognition. Dihydrotestosterone (DHT), which has been correlated with cognitive function, is significantly reduced with the use of 5 alpha reductase inhibitors (5ARI) for… read more here.
Keywords: risk dementia; use; dementia; alpha reductase ... See more keywords
May patients receiving 5-alpha-reductase inhibitors be in higher risk of COVID-19 complications?
Sign Up to like & getrecommendations! Published in 2020 at "Medical Hypotheses"
DOI: 10.1016/j.mehy.2020.109751
Abstract: Abstract COVID-19 pandemic is a major challenge for global and national healthcare providers. Number of new cases is continuously increasing with an emerging trend showing worse prognosis in males in comparison to females. Based on… read more here.
Keywords: may patients; alpha reductase; patients receiving; receiving alpha ... See more keywords
Revisiting 5α-reductase inhibitors and the risk of prostate cancer
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DOI: 10.1038/s41585-018-0018-9
Abstract: The role of 5α-reductase inhibitors (5-ARI) in prostate cancer chemoprevention remains a controversy, as cancer prevention trials with 5-ARIs have shown a decreased incidence of low-grade prostate cancer but a potential increased risk in high-grade… read more here.
Keywords: cancer; reductase inhibitors; prostate cancer; revisiting reductase ... See more keywords
Use of 5α-reductase inhibitors and survival of oesophageal and gastric cancer in a nationwide Swedish cohort study.
Sign Up to like & getrecommendations! Published in 2023 at "Acta oncologica"
DOI: 10.1080/0284186x.2023.2214681
Abstract: BACKGROUND We hypothesised that the use of the anti-androgenic drug 5α-reductase inhibitors (5-ARIs) improves survival in patients with oesophago-gastric cancer. METHODS This nationwide Swedish population-based cohort study included men who underwent surgery for oesophageal or… read more here.
Keywords: year; mortality; reductase inhibitors; gastric cancer ... See more keywords
Re: Incidence of Type 2 Diabetes Mellitus in Men Receiving Steroid 5α-Reductase Inhibitors: Population Based Cohort Study.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Urology"
DOI: 10.1097/ju.0000000000000447
Abstract: available at http://www.ncbi.nlm.nih.gov/pubmed/30971393 Editorial Comment: For the last 25 years medical therapy has been the mainstay of treatment for lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH). Virtually every guideline and regulatory… read more here.
Keywords: population based; medical therapy; type diabetes; urology ... See more keywords
PD50-10 5-α REDUCTASE INHIBITORS AND RISK OF OVERALL AND FATAL BLADDER CANCER
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Urology"
DOI: 10.1097/ju.0000000000000944.010
Abstract: INTRODUCTION AND OBJECTIVE:Previous retrospective studies have suggested that 5-α reductase inhibitors (5-ARI) might confer a protective effect on the risk of developing or dying of bladder cancer.... read more here.
Keywords: bladder cancer; reductase inhibitors; pd50 reductase;
Prediction of Inhibition Activity of Dihydrofolate Reductase Inhibitors With Multivariate Adaptive Regression Splines
Sign Up to like & getrecommendations! Published in 2023 at "IEEE Access"
DOI: 10.1109/access.2023.3272231
Abstract: Dihydrofolate reductase (DHFR) enzyme is a crucial component of cell growth and proliferation in the human body, making it an important target for treating cancer diseases. This study aims to predict the inhibitory activity (pXC50)… read more here.
Keywords: model; reductase inhibitors; activity; dihydrofolate reductase ... See more keywords