Characterization of Plasmodium knowlesi dihydrofolate reductase-thymidylate synthase and sensitivity to antifolates.
Sign Up to like & getrecommendations! Published in 2018 at "Parasitology international"
DOI: 10.1016/j.parint.2018.08.004
Abstract: Malaria caused by an infection of Plasmodium knowlesi can result in high parasitemia and deaths. Therefore, effective and prompt treatment is necessary to reduce morbidity and mortality. The study aims to characterize P. knowlesi dihydrofolate… read more here.
Keywords: sensitivity antifolates; reductase thymidylate; dihydrofolate reductase; knowlesi dihydrofolate ... See more keywords
Kaurane-Type Diterpenoids as Potential Inhibitors of Dihydrofolate Reductase-Thymidylate Synthase in New World Leishmania Species
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DOI: 10.3390/antibiotics12040663
Abstract: The bifunctional enzyme Dihydrofolate reductase-thymidylate synthase (DHFR-TS) plays a crucial role in the survival of the Leishmania parasite, as folates are essential cofactors for purine and pyrimidine nucleotide biosynthesis. However, DHFR inhibitors are largely ineffective… read more here.
Keywords: thymidylate synthase; reductase thymidylate; new world; reductase ... See more keywords