Copper-Catalyzed Asymmetric Reduction of β,β-Disubstituted Alkenylboramides.
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DOI: 10.1021/acs.orglett.9b03400
Abstract: A highly enantioselective copper-catalyzed reduction of β,β-disubstituted alkenylboron compounds was developed using hydrosilane. The copper hydride catalyst coordinated with chiral Josiphos ligand efficiently discriminated β-geminal substituents to generate corresponding β-chiral alkylboramides with excellent enantioselectivities up… read more here.
Keywords: reduction; catalyzed asymmetric; reduction disubstituted; asymmetric reduction ... See more keywords