The Effect of Retroconversion Metabolism of N-oxide Metabolites by Intestinal Microflora on Piperaquine Elimination in Mice, as well as in Humans Predicted Using a PBPK Model.
Sign Up to like & getrecommendations! Published in 2023 at "Current drug metabolism"
DOI: 10.2174/1389200224666230320112429
Abstract: BACKGROUND Piperaquine (PQ) and its pharmacologically active metabolite PQ N-oxide (PM1) can be metabolically interconverted via hepatic cytochrome P450 and FMO enzymes. OBJECTIVES The reductive metabolism of PM1 and its further N-oxidation metabolite (PM2) by… read more here.
Keywords: metabolism; oxide metabolites; reduction metabolism; elimination ... See more keywords