Cytotoxic isovaleryl sucrose esters from Ainsliaea yunnanensis: reduction of mitochondrial membrane potential and increase of reactive oxygen species levels in A549 cells
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DOI: 10.1039/c7ra01986f
Abstract: Eight isovaleryl sucrose esters, named ainslosides A–H (1–8), were isolated from Ainsliaea yunnanensis Franch. Their structures, including the absolute configurations of the sugar residues, were elucidated by extensive analysis of NMR spectra and acid hydrolysis.… read more here.
Keywords: a549 cells; reduction mitochondrial; sucrose esters; isovaleryl sucrose ... See more keywords
Empagliflozin normalizes the size and number of mitochondria and prevents reduction in mitochondrial size after myocardial infarction in diabetic hearts
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DOI: 10.14814/phy2.13741
Abstract: To explore mechanisms by which SGLT2 inhibitors protect diabetic hearts from heart failure, we examined the effect of empagliflozin (Empa) on the ultrastructure of cardiomyocytes in the noninfarcted region of the diabetic heart after myocardial… read more here.
Keywords: diabetic hearts; reduction mitochondrial; mitochondrial size; number ... See more keywords