Reduction of Nonspecificity Motifs in Synthetic Antibody Libraries.
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DOI: 10.1016/j.jmb.2017.11.008
Abstract: Successful antibody development requires both functional binding and desirable biophysical characteristics. In the current study, we analyze the causes of one hurdle to clinical development, off-target reactivity, or nonspecificity. We used a high-throughput nonspecificity assay… read more here.
Keywords: antibody; nonspecificity; motifs synthetic; reduction nonspecificity ... See more keywords