Enantio- and Regioselective CuH-Catalyzed Conjugate Reduction of Yne-Allenones.
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DOI: 10.1021/acs.orglett.1c00892
Abstract: A new asymmetric catalytic conjugate reduction of yne-allenones to synthesize enantioenriched cyclobuta[a]naphthalen-4(2H)-ones has been established that uses copper-bisphosphine complexes as catalysts and gives excellent regio- and enantioselectivities (≥99% ee) in most cases. This protocol tolerates… read more here.
Keywords: enantio regioselective; yne allenones; reduction yne; conjugate reduction ... See more keywords