Continuous-Flow Hydrogenation and Reductive Deuteration of Nitriles: a Simple Access to α,α-Dideutero Amines.
Sign Up to like & getrecommendations! Published in 2019 at "ChemPlusChem"
DOI: 10.1002/cplu.201900526
Abstract: A simple and efficient continuous flow methodology has been developed for hydrogenation and reductive deuteration of nitriles to yield primary amines and also valuable α,α-dideutero analogues. Raney nickel proved to be a useful catalyst for… read more here.
Keywords: deuteration nitriles; hydrogenation reductive; reductive deuteration; continuous flow ... See more keywords
One-Pot Sequential Hydrogen Isotope Exchange/Reductive Deuteration for the Preparation of α,β-Deuterated Alcohols using Deuterium Oxide.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01940
Abstract: An efficient one-pot sequential hydrogen isotope exchange (HIE)/reductive deuteration approach was developed for the preparation of α,β-deuterated alcohols using ketones as the precursors. The HIE step can also be used for the synthesis of α-deuterated… read more here.
Keywords: sequential hydrogen; isotope exchange; one pot; reductive deuteration ... See more keywords