Catalytic Reductive Functionalization of Tertiary Amides using Vaska’s Complex: Synthesis of Complex Tertiary Amine Building Blocks and Natural Products
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DOI: 10.1021/acscatal.0c02377
Abstract: The tertiary amide is a ubiquitous functional group and plays an irreplaceable role in medicinal chemistry. Its robust nature has meant—in the past—that selective manipulation of this motif remaine... read more here.
Keywords: using vaska; reductive functionalization; amides using; functionalization tertiary ... See more keywords
Facile preparation of pyrimidinediones and thioacrylamides via reductive functionalization of amides.
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DOI: 10.1039/c7cc04170e
Abstract: The development of an efficient protocol for the reductive functionalization of amides into pyrimidinediones and amino-substituted thioacrylamides is presented. Enamines are generated in a highly chemoselective amide hydrosilylation reaction catalyzed by molybdenum hexacarbonyl in combination… read more here.
Keywords: functionalization amides; preparation pyrimidinediones; reductive functionalization; facile preparation ... See more keywords
Mesoionic N-heterocyclic olefin catalysed reductive functionalization of CO2 for consecutive N-methylation of amines
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DOI: 10.1039/d1sc02819g
Abstract: A mesoionic N-heterocyclic olefin (mNHO) was introduced as a metal-free catalyst for the reductive functionalization of CO2 leading to consecutive double N-methylation of primary amines in the presence of 9-borabicyclo[3.3.1]nonane (9-BBN). A wide range of… read more here.
Keywords: methylation; mesoionic heterocyclic; functionalization co2; reductive functionalization ... See more keywords