Nickel-Catalyzed Multicomponent Coupling: Synthesis of α-Chiral Ketones by Reductive Hydrocarbonylation of Alkenes.
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DOI: 10.1021/jacs.1c07851
Abstract: A nickel-catalyzed, multicomponent regio- and enantioselective coupling via sequential hydroformylation and carbonylation from readily available starting materials has been developed. This modular multicomponent hydrofunctionalization strategy enables the straightforward reductive hydrocarbonylation of a broad range of… read more here.
Keywords: coupling synthesis; multicomponent coupling; nickel catalyzed; catalyzed multicomponent ... See more keywords